Acute-on-chronic liver failure in cirrhosis
Arroyo V, Moreau R, Kamath PS, Jalan R, Ginès P, Nevens F, Fernández J, To U, García-Tsao G, Schnabl B. Acute-on-chronic liver failure in cirrhosis. Nature Reviews Disease Primers 2016, 2: 16041. PMID: 27277335, DOI: 10.1038/nrdp.2016.41.Peer-Reviewed Original ResearchConceptsChronic liver failureOrgan failureAcute decompensationLiver failureHigh short-term mortalityACLF grade 2ACLF grade 3Short-term mortalityAcute liver damageCommon organ failureLiver transplantationRespiratory failureRenal failureStandard therapySystemic inflammationViral hepatitisIntestinal translocationLiver damageACLFGrade 3Consortium guidelinesMortality ratePatientsGrade 2Bacterial products