2007
Culture and Analysis of Circulating Fibrocytes
Quan TE, Bucala R. Culture and Analysis of Circulating Fibrocytes. Methods In Molecular Medicine 2007, 135: 423-434. PMID: 17951676, DOI: 10.1007/978-1-59745-401-8_28.Peer-Reviewed Original ResearchConceptsPeripheral bloodDifferent mammalian speciesMammalian speciesMatrix proteinsHematopoetic originPeripheral blood fibrocytesCultured cellsFlow cytometry analysisUnique surface phenotypeCell surface markersModel systemCirculating FibrocytesWound repairCytometry analysisBlood fibrocytesMononuclear cellsSurface phenotypeWound chambersGrowth characteristicsCellsBuffy coatFibrocytesSurface markersBloodSpecies
2006
The role of circulating fibrocytes in fibrosis
Quan TE, Cowper SE, Bucala R. The role of circulating fibrocytes in fibrosis. Current Rheumatology Reports 2006, 8: 145-150. PMID: 16569374, DOI: 10.1007/s11926-006-0055-x.Peer-Reviewed Original ResearchConceptsPulmonary fibrosisFunctions of fibrocytesAreas of inflammationSerum amyloid PTissue repair responseFibrocyte traffickingInflammatory cytokinesPeripheral bloodMalignant potentialFibrotic lesionsStromal responseIL-1Skin lesionsPathologic fibrosisNew therapiesAmyloid PHypertrophic scarsTissue damageMatrix metalloproteinasesFibrosisRemodeling responseTumor invasionFibrocytesContractile myofibroblastsExperimental model
2004
Circulating fibrocytes: collagen-secreting cells of the peripheral blood
Quan TE, Cowper S, Wu SP, Bockenstedt LK, Bucala R. Circulating fibrocytes: collagen-secreting cells of the peripheral blood. The International Journal Of Biochemistry & Cell Biology 2004, 36: 598-606. PMID: 15010326, DOI: 10.1016/j.biocel.2003.10.005.Peer-Reviewed Original ResearchConceptsNephrogenic fibrosing dermopathyAntigen-presenting cellsNaïve T cellsNew disease entityPresentation of antigensImportant etiopathogenic roleRenal insufficiencyUnique cell populationFibrosing disorderLocal tissue environmentImmunological markersInflammatory cytokinesPeripheral bloodEtiopathogenic roleFibrotic lesionsGranuloma formationAntigen presentationDisease entityT cellsHypertrophic scarsMatrix metalloproteinasesRemodeling responseFibrocytesContractile myofibroblastsCollagen-secreting cells