2023
Association of frailty with the incidence risk of cardiovascular disease and type 2 diabetes mellitus in long-term cancer survivors: a prospective cohort study
Cao X, Yang Z, Li X, Chen C, Hoogendijk E, Zhang J, Yao N, Ma L, Zhang Y, Zhu Y, Zhang X, Du Y, Wang X, Wu X, Gill T, Liu Z. Association of frailty with the incidence risk of cardiovascular disease and type 2 diabetes mellitus in long-term cancer survivors: a prospective cohort study. BMC Medicine 2023, 21: 74. PMID: 36829175, PMCID: PMC9951842, DOI: 10.1186/s12916-023-02774-1.Peer-Reviewed Original ResearchConceptsLong-term cancer survivorsType 2 diabetes mellitusCancer survivorsCardiovascular diseaseIncidence riskDiabetes mellitusFrailty IndicatorCox proportional hazards regression modelRisk of CVDProportional hazards regression modelsNon-frail participantsSerious healthcare burdenIncident cardiovascular diseaseMultivariable-adjusted modelsProspective cohort studyAssociation of frailtyPrimary care dataHazards regression modelsTime of recruitmentQuality of lifeLater comorbidityIncident T2DMCohort studyFrailty phenotypeFrailty index
2021
The Incidence and Cumulative Risk of Major Surgery in Older Persons in the United States
Becher RD, Vander Wyk B, Leo-Summers L, Desai MM, Gill TM. The Incidence and Cumulative Risk of Major Surgery in Older Persons in the United States. Annals Of Surgery 2021, 277: 87-92. PMID: 34261884, PMCID: PMC8758792, DOI: 10.1097/sla.0000000000005077.Peer-Reviewed Original ResearchConceptsMajor surgeryOlder personsCumulative riskNational HealthCommunity-living older personsHigh-quality surgical careNon-frail groupPopulation-based incidenceService Medicare beneficiariesMedicaid Services dataCumulative risk estimatesProspective longitudinal studyUnited States agesAging Trends StudyGeriatric characteristicsRepresentative incidenceFrail groupAdjusted incidenceGeriatric populationProbable dementiaSurgical carePersons 85Medicare beneficiariesSurgeryVulnerable subgroups
2020
A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries
Bhasin S, Gill TM, Reuben DB, Latham NK, Ganz DA, Greene EJ, Dziura J, Basaria S, Gurwitz JH, Dykes PC, McMahon S, Storer TW, Gazarian P, Miller ME, Travison TG, Esserman D, Carnie MB, Goehring L, Fagan M, Greenspan SL, Alexander N, Wiggins J, Ko F, Siu AL, Volpi E, Wu AW, Rich J, Waring SC, Wallace RB, Casteel C, Resnick NM, Magaziner J, Charpentier P, Lu C, Araujo K, Rajeevan H, Meng C, Allore H, Brawley BF, Eder R, McGloin JM, Skokos EA, Duncan PW, Baker D, Boult C, Correa-de-Araujo R, Peduzzi P. A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries. New England Journal Of Medicine 2020, 383: 129-140. PMID: 32640131, PMCID: PMC7421468, DOI: 10.1056/nejmoa2002183.Peer-Reviewed Original ResearchConceptsSerious fall injuriesFall injuriesIntervention groupControl groupUsual careMultifactorial interventionRate of hospitalizationPrimary care practicesCluster-randomized trialCommunity-dwelling adultsFirst-event analysisYears of ageHealth care systemRate of fallElectronic health recordsBaseline characteristicsPrimary outcomeRandomized trialsMean ageEfficacy trialsIndividualized planCare practicesInjuryMultifactorial strategyEvent rates
2017
Association of Accelerometry‐Measured Physical Activity and Cardiovascular Events in Mobility‐Limited Older Adults: The LIFE (Lifestyle Interventions and Independence for Elders) Study
Cochrane S, Chen S, Fitzgerald J, Dodson J, Fielding R, King A, McDermott M, Manini T, Marsh A, Newman A, Pahor M, Tudor‐Locke C, Ambrosius W, Buford T, Espeland M, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler J, Hsu F, Lovato L, Roberson W, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Pierce J, Romashkan S, Patel K, Bonds D, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Butitta B, Donatto S, Cocreham S, Castro C, Haskell W, Stafford R, Pruitt L, Berra K, Yank V, Anton S, Nayfield S, Marsiske M, Sandesara B, Knaggs J, Lorow M, Marena W, Korytov I, Morris H, Fitch M, Singletary F, Causer J, Radcliff K, Studenski S, Goodpaster B, Glynn N, Lopez O, Nadkarni N, Williams K, Newman M, Grove G, Bonk J, Rush J, Kost P, Ives D, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer‐Skinner R, Wrights A, Fries R, Barr D, Axtell R, Kashaf S, de Rekeneire N, McGloin J, Wu K, Shepard D, Fennelly B, Iannone L, Mautner R, Barnett T, Halpin S, Brennan M, Bugaj J, Zenoni M, Mignosa B, Sink K, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Wilson V, Handberg E, Flynn G, Gill T, Hankinson J, Fragoso C, Kaplan R. Association of Accelerometry‐Measured Physical Activity and Cardiovascular Events in Mobility‐Limited Older Adults: The LIFE (Lifestyle Interventions and Independence for Elders) Study. Journal Of The American Heart Association 2017, 6: e007215. PMID: 29197830, PMCID: PMC5779035, DOI: 10.1161/jaha.117.007215.Peer-Reviewed Original ResearchMeSH KeywordsActigraphyAge FactorsAgedAged, 80 and overAgingCardiovascular DiseasesExerciseExercise TherapyFemaleFitness TrackersGeriatric AssessmentHealth Knowledge, Attitudes, PracticeHumansIncidenceMaleMobility LimitationPatient Education as TopicPredictive Value of TestsPrognosisProtective FactorsRisk FactorsRisk Reduction BehaviorTime FactorsUnited StatesConceptsCardiovascular eventsPhysical activityOlder adultsLower incidenceLower cardiovascular event ratesCardiovascular event ratesCardiovascular risk factorsSubsequent cardiovascular eventsMedical record reviewHealth education interventionHip-worn accelerometersPhysical activity surveillanceLife Study participantsMonths postrandomizationLife studiesRecord reviewRisk factorsDaily PAStudy participantsEvent ratesMobility limitationsEducation interventionLongitudinal associationsBaselineActivity surveillance