2023
Pragmatic evaluation of events and benefits of lipid lowering in older adults (PREVENTABLE): Trial design and rationale
Joseph J, Pajewski N, Dolor R, Sellers M, Perdue L, Peeples S, Henrie A, Woolard N, Jones W, Benziger C, Orkaby A, Mixon A, VanWormer J, Shapiro M, Kistler C, Polonsky T, Chatterjee R, Chamberlain A, Forman D, Knowlton K, Gill T, Newby L, Hammill B, Cicek M, Williams N, Decker J, Ou J, Rubinstein J, Choudhary G, Gazmuri R, Schmader K, Roumie C, Vaughan C, Effron M, Cooper‐DeHoff R, Supiano M, Shah R, Whittle J, Hernandez A, Ambrosius W, Williamson J, Alexander K, Group P. Pragmatic evaluation of events and benefits of lipid lowering in older adults (PREVENTABLE): Trial design and rationale. Journal Of The American Geriatrics Society 2023, 71: 1701-1713. PMID: 37082807, PMCID: PMC10258159, DOI: 10.1111/jgs.18312.Peer-Reviewed Original ResearchConceptsOlder adultsHigh-intensity statin therapyRandomized pragmatic clinical trialCognitive testingBenefits of lipidInitiation of statinsBenefits of statinsNational Death Index searchEffect of statinsPragmatic clinical trialsCommunity-dwelling adultsMild cognitive impairmentLow participant burdenBaseline cognitive testingElectronic health recordsCardiovascular deathCardiovascular eventsCoronary revascularizationLipid panelStatin therapyStatin useUnstable anginaHeart failurePrimary outcomeMyocardial infarction
2017
Association of Accelerometry‐Measured Physical Activity and Cardiovascular Events in Mobility‐Limited Older Adults: The LIFE (Lifestyle Interventions and Independence for Elders) Study
Cochrane S, Chen S, Fitzgerald J, Dodson J, Fielding R, King A, McDermott M, Manini T, Marsh A, Newman A, Pahor M, Tudor‐Locke C, Ambrosius W, Buford T, Espeland M, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler J, Hsu F, Lovato L, Roberson W, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Pierce J, Romashkan S, Patel K, Bonds D, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Butitta B, Donatto S, Cocreham S, Castro C, Haskell W, Stafford R, Pruitt L, Berra K, Yank V, Anton S, Nayfield S, Marsiske M, Sandesara B, Knaggs J, Lorow M, Marena W, Korytov I, Morris H, Fitch M, Singletary F, Causer J, Radcliff K, Studenski S, Goodpaster B, Glynn N, Lopez O, Nadkarni N, Williams K, Newman M, Grove G, Bonk J, Rush J, Kost P, Ives D, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer‐Skinner R, Wrights A, Fries R, Barr D, Axtell R, Kashaf S, de Rekeneire N, McGloin J, Wu K, Shepard D, Fennelly B, Iannone L, Mautner R, Barnett T, Halpin S, Brennan M, Bugaj J, Zenoni M, Mignosa B, Sink K, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Wilson V, Handberg E, Flynn G, Gill T, Hankinson J, Fragoso C, Kaplan R. Association of Accelerometry‐Measured Physical Activity and Cardiovascular Events in Mobility‐Limited Older Adults: The LIFE (Lifestyle Interventions and Independence for Elders) Study. Journal Of The American Heart Association 2017, 6: e007215. PMID: 29197830, PMCID: PMC5779035, DOI: 10.1161/jaha.117.007215.Peer-Reviewed Original ResearchMeSH KeywordsActigraphyAge FactorsAgedAged, 80 and overAgingCardiovascular DiseasesExerciseExercise TherapyFemaleFitness TrackersGeriatric AssessmentHealth Knowledge, Attitudes, PracticeHumansIncidenceMaleMobility LimitationPatient Education as TopicPredictive Value of TestsPrognosisProtective FactorsRisk FactorsRisk Reduction BehaviorTime FactorsUnited StatesConceptsCardiovascular eventsPhysical activityOlder adultsLower incidenceLower cardiovascular event ratesCardiovascular event ratesCardiovascular risk factorsSubsequent cardiovascular eventsMedical record reviewHealth education interventionHip-worn accelerometersPhysical activity surveillanceLife Study participantsMonths postrandomizationLife studiesRecord reviewRisk factorsDaily PAStudy participantsEvent ratesMobility limitationsEducation interventionLongitudinal associationsBaselineActivity surveillance