The disrupted molecular circadian clock of monocytes and macrophages in allergic inflammation
Teppan J, Schwanzer J, Rittchen S, Bärnthaler T, Lindemann J, Nayak B, Reiter B, Luschnig P, Farzi A, Heinemann A, Sturm E. The disrupted molecular circadian clock of monocytes and macrophages in allergic inflammation. Frontiers In Immunology 2024, 15: 1408772. PMID: 38863703, PMCID: PMC11165079, DOI: 10.3389/fimmu.2024.1408772.Peer-Reviewed Original ResearchPolarized macrophagesHuman peripheral blood monocytesPrecision cut lung slicesMacrophage inflammatory proteinPeripheral blood monocytesChronic pulmonary diseaseInflammatory lung diseasesLung-protective propertiesTissue-resident macrophagesM2-polarized macrophagesMolecular circadian clockHuman monocyte-derived macrophagesHouse dust mite modelMonocyte-derived macrophagesCircadian protein CLOCKAllergic asthmaticsAllergic inflammationBlood monocytesEffector functionsLung diseaseInflammatory disordersMacrophage dysfunctionProtein expression patternsAllergic donorsTherapeutic approaches