Notching up on the cellular origins of intrahepatic cholangiocarcinoma
Sirica A, Groszmann R, Iwakiri Y, Taddei T. Notching up on the cellular origins of intrahepatic cholangiocarcinoma. Hepatology 2013, 57: 1668-1671. PMID: 23390051, DOI: 10.1002/hep.26313.Peer-Reviewed Original ResearchOrigin of intrahepatic cholangiocarcinomaBiliary lineage cellsLiver progenitor cellsBiliary epithelial cellsIntrahepatic cholangiocarcinomaCell type-specific reportersMouse modelLineage cellsCellular originMouse model of intrahepatic cholangiocarcinomaPrimary liver tumorsActivated NotchDevelopment of effective therapiesNotch activationAkt signalingLiver cell typesCell typesRefractory diseasePrimary malignancyPoor prognosisViral hepatitisLiver tumorsMalignant tumorsEffective therapyProgenitor cells