2020
Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation
Gu SX, Tyagi T, Jain K, Gu VW, Lee SH, Hwa JM, Kwan JM, Krause DS, Lee AI, Halene S, Martin KA, Chun HJ, Hwa J. Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation. Nature Reviews Cardiology 2020, 18: 194-209. PMID: 33214651, PMCID: PMC7675396, DOI: 10.1038/s41569-020-00469-1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAdministration, InhalationAnticoagulantsBlood Coagulation DisordersBlood Platelet DisordersCOVID-19COVID-19 Drug TreatmentEndothelium, VascularEndothelium-Dependent Relaxing FactorsEpoprostenolHeart Disease Risk FactorsHumansIloprostInflammationNitric OxidePlatelet Aggregation InhibitorsSARS-CoV-2Systemic Inflammatory Response SyndromeThrombosisThrombotic MicroangiopathiesVascular DiseasesVasodilator AgentsVenous ThromboembolismConceptsCardiovascular risk factorsRisk factorsCOVID-19Severe acute respiratory syndrome coronavirus 2Pre-existing cardiovascular diseaseAcute respiratory syndrome coronavirus 2Traditional cardiovascular risk factorsAcute respiratory distress syndromeRespiratory syndrome coronavirus 2Respiratory distress syndromeManagement of patientsSyndrome coronavirus 2COVID-19 pathologyCoronavirus disease 2019Potential therapeutic strategyCytokine stormEndothelial dysfunctionThrombotic complicationsDistress syndromeExcessive inflammationCoronavirus 2Severe outcomesAdvanced ageCardiovascular diseaseDisease 2019
2016
Adding insult to injury: autoimmune haemolytic anaemia complicated by pulmonary embolism
Woodson KA, Lee Y, Gopalratnam K, Halene S. Adding insult to injury: autoimmune haemolytic anaemia complicated by pulmonary embolism. BMJ Case Reports 2016, 2016: bcr2015213575. PMID: 26768839, PMCID: PMC4735441, DOI: 10.1136/bcr-2015-213575.Peer-Reviewed Case Reports and Technical NotesConceptsAutoimmune haemolytic anaemiaOwn red blood cellsPulmonary embolismPulmonary hypertensionVenous thromboembolismHaemolytic anaemiaPatient's own red blood cellsSevere right ventricular dysfunctionNitric oxideRight ventricular dysfunctionNitric oxide treatmentClot burdenHaemodynamic compromiseVentricular dysfunctionRed blood cellsDeadly complicationPathological antibodiesChronic mannerAnemiaBlood cellsHypertensionEmbolismPossible benefitsTreatmentOxide treatment