2018
Ganetespib limits ciliation and cystogenesis in autosomal‐dominant polycystic kidney disease (ADPKD)
Nikonova AS, Deneka AY, Kiseleva AA, Korobeynikov V, Gaponova A, Serebriiskii IG, Kopp MC, Hensley HH, Seeger‐Nukpezah T, Somlo S, Proia DA, Golemis EA. Ganetespib limits ciliation and cystogenesis in autosomal‐dominant polycystic kidney disease (ADPKD). The FASEB Journal 2018, 32: 2735-2746. PMID: 29401581, PMCID: PMC5901382, DOI: 10.1096/fj.201700909r.Peer-Reviewed Original ResearchConceptsAutosomal dominant polycystic kidney diseasePolycystic kidney diseaseKidney diseaseEnd-stage renal diseaseLoss of Pkd1Conditional mouse modelHeat shock protein-90 clientsRenal diseaseKidney enlargementClinical Hsp90 inhibitorsRenal cystsAmeliorated symptomsMouse modelNew biologic activityCiliary lossCystic growthDiseaseBiologic activityGlycolysis inhibitorGanetespibADPKD pathogenesisVivo lossHsp90 inhibitorsHsp90 inhibitionRenal cilia
2013
Chapter 80 Autosomal Dominant Polycystic Kidney Disease
Somlo S, Torres V, Caplan M. Chapter 80 Autosomal Dominant Polycystic Kidney Disease. 2013, 2645-2688. DOI: 10.1016/b978-0-12-381462-3.00080-x.Peer-Reviewed Original ResearchAutosomal dominant polycystic kidney diseaseDominant polycystic kidney diseaseKidney diseasePolycystic kidney diseaseStructural kidney diseaseMultiple renal cystsAortic root dilatationTherapeutic clinical trialsMitral valve prolapseAbdominal wall herniasLiver bile ductsAge-dependent occurrenceBasic disease mechanismsNoncystic manifestationsRoot dilatationBile ductPolycystic liverSystemic disordersValve prolapseExtrarenal manifestationsClinical trialsPancreatic ductWall herniasRenal cystsClinical disease