2024
Prognostic Models for Mortality and Morbidity in Heart Failure With Preserved Ejection Fraction
McDowell K, Kondo T, Talebi A, Teh K, Bachus E, de Boer R, Campbell R, Claggett B, Desai A, Docherty K, Hernandez A, Inzucchi S, Kosiborod M, Lam C, Martinez F, Simpson J, Vaduganathan M, Jhund P, Solomon S, McMurray J. Prognostic Models for Mortality and Morbidity in Heart Failure With Preserved Ejection Fraction. JAMA Cardiology 2024, 9: 457-465. PMID: 38536153, PMCID: PMC10974691, DOI: 10.1001/jamacardio.2024.0284.Peer-Reviewed Original ResearchMeSH KeywordsCause of DeathHeart Failure, DiastolicHumansMaleModels, CardiovascularPrognosisProportional Hazards ModelsConceptsNT-proBNP levelsHF hospitalizationHeart failureCardiovascular deathNT-proBNPPARAGON-HFClinical outcomesN-terminal pro-brain natriuretic peptideAngiotensin receptor-neprilysin inhibitionComposite of HF hospitalizationSodium-glucose cotransporter 2 inhibitorsHigh-sensitivity cardiac troponin TMeta-Analysis Global GroupPro-brain natriuretic peptidePARAGON-HF trialBiomarker-driven approachesRisk of cardiovascular deathHigh-risk patientsInformed care decisionsCardiac troponin TPredictive of all-causePredictive of morbidityTransient ischemic attack/strokeChronic obstructive pulmonary diseaseObstructive pulmonary disease
2022
IGFBP-7 and Outcomes in Heart Failure With Reduced Ejection Fraction Findings From DAPA-HF
Adamson C, Welsh P, Docherty K, de Boer R, Diez M, Drożdż J, Dukát A, Inzucchi S, Køber L, Kosiborod M, Ljungman C, Martinez F, Ponikowski P, Sabatine M, Morrow D, Lindholm D, Hammarstedt A, Boulton D, Greasley P, Langkilde A, Solomon S, Sattar N, McMurray J, Jhund P. IGFBP-7 and Outcomes in Heart Failure With Reduced Ejection Fraction Findings From DAPA-HF. JACC Heart Failure 2022, 11: 291-304. PMID: 36592046, DOI: 10.1016/j.jchf.2022.09.004.Peer-Reviewed Original ResearchMeSH KeywordsHeart FailureHumansInsulin-Like Growth Factor Binding ProteinsProportional Hazards ModelsStroke VolumeVentricular Dysfunction, LeftConceptsInsulin-like growth factor-binding protein 7IGFBP-7 levelsHeart failureN-terminal pro-B-type natriuretic peptidePro-B-type natriuretic peptideHigh-sensitivity troponin TCox proportional hazards modelBenefit of dapagliflozinDAPA-HF trialEjection fraction (EF) findingsIGFBP-7 concentrationsWorse clinical profileReduced ejection fractionAdverse clinical outcomesPotential prognostic biomarkerProportional hazards modelAdvanced HFrEFDAPA-HFCardiovascular deathHF outcomesNT-proBNPPrimary endpointClinical profileEjection fractionHighest tertile