In‐hospital course of patients with heart failure with improved ejection fraction in the DELIVER trial
Pabon M, Vaduganathan M, Claggett B, Chatur S, Siqueira S, Marti‐Castellote P, de Boer R, Hernandez A, Inzucchi S, Kosiborod M, Lam C, Martinez F, Shah S, Desai A, Jhund P, McMurray J, Solomon S, Vardeny O. In‐hospital course of patients with heart failure with improved ejection fraction in the DELIVER trial. European Journal Of Heart Failure 2024 PMID: 39300780, DOI: 10.1002/ejhf.3410.Peer-Reviewed Original ResearchLeft ventricular ejection fractionCourse of patientsIn-hospital courseHF hospitalizationHeart failureIn-hospital mortalityEjection fractionClinical courseLeft ventricular ejection fraction changesLeft ventricular ejection fraction measurementsClinical course of patientsIn-hospital clinical courseRisk of clinical eventsMechanical fluid removalStandard diuretic therapyMedian follow-upVentricular ejection fractionNon-invasive ventilationIntensive care unitClinical Endpoint CommitteeTime of enrollmentMechanical circulatory supportLength of stayDiuretic therapyHFimpEFDapagliflozin and Mode of Death in Heart Failure With Improved Ejection Fraction
Vardeny O, Desai A, Jhund P, Fang J, Claggett B, de Boer R, Hernandez A, Inzucchi S, Kosiborod M, Lam C, Martinez F, Shah S, Mc Causland F, Petrie M, Vaduganathan M, McMurray J, Solomon S. Dapagliflozin and Mode of Death in Heart Failure With Improved Ejection Fraction. JAMA Cardiology 2024, 9: 283-289. PMID: 38265835, PMCID: PMC10809142, DOI: 10.1001/jamacardio.2023.5318.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionMode of deathEjection fractionCause-specific deathHeart failureCardiovascular deathNew York Heart Association class IIGuideline-directed medical therapyStudy case report formsSudden deathVentricular ejection fractionRate of sudden deathAssociated with lower ratesCox regression modelsImproved ejection fractionRandomized clinical trialsReduce cardiovascular mortalityCase report formsEnd-point committeeClinical end point committeePost hoc analysisDapagliflozin EvaluationIV symptomsHFimpEFMedical therapy