Involvement of Phenylalanine 272 of DNA Polymerase Beta in Discriminating between Correct and Incorrect Deoxynucleoside Triphosphates †
Li S, Vaccaro J, Sweasy J. Involvement of Phenylalanine 272 of DNA Polymerase Beta in Discriminating between Correct and Incorrect Deoxynucleoside Triphosphates †. Biochemistry 1999, 38: 4800-4808. PMID: 10200168, DOI: 10.1021/bi9827058.Peer-Reviewed Original ResearchConceptsDNA polymerase betaPolymerase betaWild typeVivo genetic screenWild-type enzymeBase excision repairDeoxynucleoside triphosphatesGenetic screenBase substitution mutationsMutator mutantsGround-state bindingType enzymeExcision repairResidue 272Substitution mutationsIncorrect dNTPMutantsDecreased fidelityFrameshift mutation