2016
ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells
Boddupalli CS, Nair S, Gray SM, Nowyhed HN, Verma R, Gibson JA, Abraham C, Narayan D, Vasquez J, Hedrick CC, Flavell RA, Dhodapkar KM, Kaech SM, Dhodapkar MV. ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells. Journal Of Clinical Investigation 2016, 126: 3905-3916. PMID: 27617863, PMCID: PMC5096804, DOI: 10.1172/jci85329.Peer-Reviewed Original ResearchConceptsTissue-resident memory T cellsMemory T cellsT cellsTRM cellsCellular therapyAdoptive cellular therapyImmune-deficient micePotential cellular therapySP T cellsSide population cellsHuman T cellsPutative subsetsAdoptive transferDistinct gene expression profilesCell mobilizationImmune surveillanceQuiescent subsetPopulation cellsMiceTherapyQuiescent phenotypeDistinct subsetsMember 1Nuclear receptorsSignature genes
2014
Type II NKT-TFH cells against Gaucher lipids regulate B-cell immunity and inflammation
Nair S, Boddupalli CS, Verma R, Liu J, Yang R, Pastores GM, Mistry PK, Dhodapkar MV. Type II NKT-TFH cells against Gaucher lipids regulate B-cell immunity and inflammation. Blood 2014, 125: 1256-1271. PMID: 25499455, PMCID: PMC4335081, DOI: 10.1182/blood-2014-09-600270.Peer-Reviewed Original ResearchConceptsI NKT cellsNKT cellsB cell activationT cellsB cellsTetramer-positive T cellsType II natural killer T cellsT cell receptor usageType I NKT cellsType II NKT cellsNatural killer T cellsFollicular helper phenotypeGD mouse modelMetabolic lipid disordersKiller T cellsB cell immunityGerminal center B cellsB-cell malignanciesAntilipid antibodiesDisease activityCytokine profileChronic inflammationHelper phenotypeHumoral immunityCognate help
2010
Glutathione-Redox Balance Regulates c-rel–Driven IL-12 Production in Macrophages: Possible Implications in Antituberculosis Immunotherapy
Alam K, Ghousunnissa S, Nair S, Valluri VL, Mukhopadhyay S. Glutathione-Redox Balance Regulates c-rel–Driven IL-12 Production in Macrophages: Possible Implications in Antituberculosis Immunotherapy. The Journal Of Immunology 2010, 184: 2918-2929. PMID: 20164428, DOI: 10.4049/jimmunol.0900439.Peer-Reviewed Original ResearchConceptsIL-12 productionImmune responseGlutathione redox balanceEnhanced Th1 responseProtective Th1 typeTNF-alpha levelsCellular immune responsesIFN-gamma productionIL-12 inductionBacillus Calmette-GuérinIL-12 cytokinesActive tuberculosisTh1 responseTh1 typeGlutathione ethyl esterNAC treatmentP70 productionCalmette-GuérinIntracellular reduced glutathioneP65 NF-kappaB.Pathophysiological disordersNF-kappaB.IkappaBalpha phosphorylationGSH donorMacrophages
2006
Nitric oxide inhibits interleukin-12 p40 through p38 MAPK-mediated regulation of calmodulin and c-rel
Boddupalli CS, Ghosh S, Rahim S, Nair S, Ehtesham NZ, Hasnain SE, Mukhopadhyay S. Nitric oxide inhibits interleukin-12 p40 through p38 MAPK-mediated regulation of calmodulin and c-rel. Free Radical Biology And Medicine 2006, 42: 686-697. PMID: 17291992, DOI: 10.1016/j.freeradbiomed.2006.12.014.Peer-Reviewed Original Research