2013
Endocytosis of Mycobacterium tuberculosis Heat Shock Protein 60 Is Required to Induce Interleukin-10 Production in Macrophages*
Parveen N, Varman R, Nair S, Das G, Ghosh S, Mukhopadhyay S. Endocytosis of Mycobacterium tuberculosis Heat Shock Protein 60 Is Required to Induce Interleukin-10 Production in Macrophages*. Journal Of Biological Chemistry 2013, 288: 24956-24971. PMID: 23846686, PMCID: PMC3750191, DOI: 10.1074/jbc.m113.461004.Peer-Reviewed Original ResearchConceptsToll-like receptorsIL-10 productionPro-inflammatory responseHeat shock protein 60Shock protein 60Immune responseInnate responseHost protective immune responsesProtein 60Interleukin-10 productionType immune responseProtective immune responseProduction of interleukinAnti-tuberculosis immunityTumor necrosis factorInnate immune responseMacrophage innate responsesMycobacterium tuberculosis bacteriaTLR4 receptorNecrosis factorP38 MAPK activationTLR2M. tuberculosisTuberculosis bacteriaP38 MAPK
2012
Pathogenesis in tuberculosis: transcriptomic approaches to unraveling virulence mechanisms and finding new drug targets
Mukhopadhyay S, Nair S, Ghosh S. Pathogenesis in tuberculosis: transcriptomic approaches to unraveling virulence mechanisms and finding new drug targets. FEMS Microbiology Reviews 2012, 36: 463-485. PMID: 22092372, DOI: 10.1111/j.1574-6976.2011.00302.x.Peer-Reviewed Original ResearchConceptsMajor health problemHost immune responseEmergence of strainsDrug targetsDendritic cellsEffective drug targetsInhibition of apoptosisImmune responseNew drug targetsHealth problemsLipid metabolismMultiple drugsTuberculosisComplex etiologyMycobacterium tuberculosisIntracellular life styleTranscriptome signaturesVirulence mechanismsGenome-wide expression profilingDrugsAntibiotic drugsExpression profilingProtein secretionLife stylePoor understanding
2010
Glutathione-Redox Balance Regulates c-rel–Driven IL-12 Production in Macrophages: Possible Implications in Antituberculosis Immunotherapy
Alam K, Ghousunnissa S, Nair S, Valluri VL, Mukhopadhyay S. Glutathione-Redox Balance Regulates c-rel–Driven IL-12 Production in Macrophages: Possible Implications in Antituberculosis Immunotherapy. The Journal Of Immunology 2010, 184: 2918-2929. PMID: 20164428, DOI: 10.4049/jimmunol.0900439.Peer-Reviewed Original ResearchConceptsIL-12 productionImmune responseGlutathione redox balanceEnhanced Th1 responseProtective Th1 typeTNF-alpha levelsCellular immune responsesIFN-gamma productionIL-12 inductionBacillus Calmette-GuérinIL-12 cytokinesActive tuberculosisTh1 responseTh1 typeGlutathione ethyl esterNAC treatmentP70 productionCalmette-GuérinIntracellular reduced glutathioneP65 NF-kappaB.Pathophysiological disordersNF-kappaB.IkappaBalpha phosphorylationGSH donorMacrophages
2008
Association of Strong Immune Responses to PPE Protein Rv1168c with Active Tuberculosis ▿
Khan N, Alam K, Nair S, Valluri VL, Murthy KJ, Mukhopadhyay S. Association of Strong Immune Responses to PPE Protein Rv1168c with Active Tuberculosis ▿. MSphere 2008, 15: 974-980. PMID: 18400969, PMCID: PMC2446626, DOI: 10.1128/cvi.00485-07.Peer-Reviewed Original ResearchConceptsTB patientsESAT-6Sensitized peripheral blood mononuclear cellsStrong gamma interferon responseSmear-negative pulmonary TBPeripheral blood mononuclear cellsExtrapulmonary TB casesSerodiagnosis of TBBlood mononuclear cellsPotent T-cell antigenControl of TBT-cell antigensGamma interferon responseStrong immune responseConventional diagnostic testsConventional enzyme immunoassayActive TBMycobacterium bovis BCGPulmonary TBActive tuberculosisTB casesTuberculosis infectionMononuclear cellsImmune responseStrong immunoreactivity