2016
Silibinin induces mitochondrial NOX4-mediated endoplasmic reticulum stress response and its subsequent apoptosis
Kim S, Kim K, Yu S, Seo Y, Chun S, Yu H, Ahn S. Silibinin induces mitochondrial NOX4-mediated endoplasmic reticulum stress response and its subsequent apoptosis. BMC Cancer 2016, 16: 452. PMID: 27405931, PMCID: PMC4942927, DOI: 10.1186/s12885-016-2516-6.Peer-Reviewed Original ResearchConceptsReactive oxygen speciesNOX4 expressionDisruption of Ca2ER stress responseProstate cancer PC-3 cellsCancer PC-3 cellsRegulation of NOX4Inhibited tumor growthCell linesPC-3 cellsProstate cell linesSilibinin-induced apoptosisProduction of ROSEndoplasmic reticulum stress responseExpression of apoptosisCancer cell linesProstate cancerROS-dependent apoptosisChemopreventive effectsMitochondrial Nox4Mitochondrial reactive oxygen speciesReticulum stress responseTumor growthFlow cytometryMethodsThe effects
2015
Autophagy inhibition enhances silibinin-induced apoptosis by regulating reactive oxygen species production in human prostate cancer PC-3 cells
Kim S, Kim K, Yu S, Park S, Choi H, Ji J, Ahn S. Autophagy inhibition enhances silibinin-induced apoptosis by regulating reactive oxygen species production in human prostate cancer PC-3 cells. Biochemical And Biophysical Research Communications 2015, 468: 151-156. PMID: 26522224, DOI: 10.1016/j.bbrc.2015.10.143.Peer-Reviewed Original ResearchConceptsPC-3 cellsProstate cancer PC-3 cellsCancer PC-3 cellsAcidic vesicular organellesSilibinin-induced apoptosisReactive oxygen speciesAnticancer effectsHuman prostate cancer PC-3 cellsMicrotubule-associated protein 1 light chain 3Inhibition of ROSProtein 1 light chain 3Major bioactive componentsInhibition of autophagyReactive oxygen species productionCancer cell linesLight chain 3Supportive therapyLiver conditionsOxygen species productionCancer modelProtective roleSilibininSilibinin-induced autophagyROS inhibitorChain 3
2013
Silibinin induces endoplasmic reticulum stress‐mediated and mitochondrial‐mediated apoptosis through disruption of Ca2+ homeostasis in human prostate cancer PC‐3 cells
Kim S, Kim K, Yu S, Park S, Kong I, Ahn S. Silibinin induces endoplasmic reticulum stress‐mediated and mitochondrial‐mediated apoptosis through disruption of Ca2+ homeostasis in human prostate cancer PC‐3 cells. The FASEB Journal 2013, 27: lb103-lb103. DOI: 10.1096/fasebj.27.1_supplement.lb103.Peer-Reviewed Original ResearchPC-3 cellsHuman prostate cancer PC-3 cellsProstate cancer PC-3 cellsSilibinin-induced apoptosisCancer PC-3 cellsER stress-related proteinsStress-related proteinsReactive oxygen speciesER stressDNA damage-inducible gene 153Cancer cellsRWPE-1 cellsChelator BAPTA/AMProstate cancer cellsDrug-induced lethalityGlucose-regulated protein 78Mitochondrial-mediated apoptosisFlow cytometric analysisMitochondrial membrane potentialApoptosis-related proteinsBAPTA/AMCancer cell linesSilibinin treatmentChemopreventive effectsDisruption of Ca2