Ryan MacLeod, MD, PhD
he/him/his
Clinical Fellow T32About
Research
Publications
2026
14-3-3ε as an intracellular mediator of PGRN/TNFR2 signaling in bone fracture healing
He C, Fu W, Cui X, Moradi L, Bi J, MacLeod R, Liu C. 14-3-3ε as an intracellular mediator of PGRN/TNFR2 signaling in bone fracture healing. Genes & Diseases 2026, 102408. DOI: 10.1016/j.gendis.2026.102408.Peer-Reviewed Original ResearchVepdegestrant for ESR1-mutated breast cancer
MacLeod R, Liu C. Vepdegestrant for ESR1-mutated breast cancer. Trends In Pharmacological Sciences 2026, 47: 940-941. PMID: 42431763, PMCID: PMC13360994, DOI: 10.1016/j.tips.2026.06.009.Peer-Reviewed Original ResearchTiming of Denosumab Therapy in Relation to Parathyroidectomy in the Setting of Primary Hyperparathyroidism: Case Report
MacLeod R, Ramirez A, Gulanski B, Majumdar S. Timing of Denosumab Therapy in Relation to Parathyroidectomy in the Setting of Primary Hyperparathyroidism: Case Report. Case Reports In Endocrinology 2026, 2026: 8562872. PMID: 42256324, PMCID: PMC13239141, DOI: 10.1155/crie/8562872.Peer-Reviewed Original Research
2025
TNFR2 signaling in musculoskeletal diseases: Implications for rheumatoid arthritis and osteoarthritis
Qian E, MacLeod R, Liu C. TNFR2 signaling in musculoskeletal diseases: Implications for rheumatoid arthritis and osteoarthritis. Journal Of Leukocyte Biology 2025, 118: qiaf178. PMID: 41384366, PMCID: PMC12850386, DOI: 10.1093/jleuko/qiaf178.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsIodine for the Outpatient Management of Graves’ Disease: A Case Series of 7 Patients
Magvanjav O, MacLeod R, Balasubramanian P, Mekala K, Peter P, Inzucchi S, Majumdar S. Iodine for the Outpatient Management of Graves’ Disease: A Case Series of 7 Patients. AACE Endocrinology And Diabetes 2025, 13: 83-87. PMID: 41641309, PMCID: PMC12866150, DOI: 10.1016/j.aed.2025.10.015.Peer-Reviewed Original ResearchLocal Production of Osteoprotegerin by Osteoblasts Suppresses Bone Resorption
Cawley K, Bustamante-Gomez N, Guha A, MacLeod R, Xiong J, Gubrij I, Liu Y, Mulkey R, Palmieri M, Thostenson J, Goellner J, O’Brien C. Local Production of Osteoprotegerin by Osteoblasts Suppresses Bone Resorption. Cell Reports 2025, 44: 115821. PMID: 40440173, PMCID: PMC12286569, DOI: 10.1016/j.celrep.2025.115821.Commentaries, Editorials and Letters
2024
Discontinuation of Denosumab
MacLeod RS, Gulanski BI. Clinical Overview: Discontinuation of Denosumab. ClinicalKey. Updated September, 23,2024. Published October 11, 2024. https://www.clinicalkey.com/#!/content/clinical_overview/67-s2.0-V2747Peer-Reviewed Educational Materials
2023
A Ticklish Parrot-dox: Dual Diagnosis of Lyme Carditis and Psittacosis
Tran P, Maayah M, MacLeod R, Frampton J. A Ticklish Parrot-dox: Dual Diagnosis of Lyme Carditis and Psittacosis. Journal Of Brown Hospital Medicine 2023, 2: 72765. PMID: 40046139, PMCID: PMC11878842, DOI: 10.56305/001c.72765.Peer-Reviewed Original Research
2022
Loss of chaperone-mediated autophagy is associated with low vertebral cancellous bone mass
Akel N, MacLeod R, Berryhill S, Laster D, Dimori M, Crawford J, Fu Q, Onal M. Loss of chaperone-mediated autophagy is associated with low vertebral cancellous bone mass. Scientific Reports 2022, 12: 3134. PMID: 35210514, PMCID: PMC8873216, DOI: 10.1038/s41598-022-07157-9.Peer-Reviewed Original Research
2021
Deletion of a putative promoter-proximal Tnfsf11 regulatory region in mice does not alter bone mass or Tnfsf11 expression in vivo
MacLeod RS, Meyer MB, Xiong J, Cawley KM, Liu Y, Onal M, Benkusky NA, Thostenson JD, Pike JW, O’Brien C. Deletion of a putative promoter-proximal Tnfsf11 regulatory region in mice does not alter bone mass or Tnfsf11 expression in vivo. PLOS ONE 2021, 16: e0250974. PMID: 33970941, PMCID: PMC8109787, DOI: 10.1371/journal.pone.0250974.Peer-Reviewed Original Research
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Yale School of Medicine
333 Cedar Street
New Haven, Connecticut 06510
United States