2003
MRI and PET Study of Deficits in Hippocampal Structure and Function in Women With Childhood Sexual Abuse and Posttraumatic Stress Disorder
Bremner JD, Vythilingam M, Vermetten E, Southwick SM, McGlashan T, Nazeer A, Khan S, Vaccarino LV, Soufer R, Garg PK, Ng CK, Staib LH, Duncan JS, Charney DS. MRI and PET Study of Deficits in Hippocampal Structure and Function in Women With Childhood Sexual Abuse and Posttraumatic Stress Disorder. American Journal Of Psychiatry 2003, 160: 924-932. PMID: 12727697, DOI: 10.1176/appi.ajp.160.5.924.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderChildhood sexual abuseHippocampal volumeEarly childhood sexual abuseHippocampal structureHippocampal functionAbuse-related posttraumatic stress disorderStress disorderSmaller hippocampal volumesPositron emission tomographySexual abuseVerbal declarative memory tasksAnimal studiesBrain areasDeclarative memory taskEmission tomographyPET studiesHippocampal activationWomenEarly stressHippocampusAbused womenDisordersAbuseMagnetic resonance
2001
Reproducibility of in vivo brain measures of 5-HT2A receptors with PET and [18F]deuteroaltanserin
Soares J, van Dyck C, Tan P, Zoghbi S, Garg P, Soufer R, Baldwin R, Fujita M, Staley J, Fu X, Amici L, Seibyl J, Innis R. Reproducibility of in vivo brain measures of 5-HT2A receptors with PET and [18F]deuteroaltanserin. Psychiatry Research 2001, 106: 81-93. PMID: 11306248, DOI: 10.1016/s0925-4927(01)00071-3.Peer-Reviewed Original ResearchConceptsTest/retest reproducibilityPositron emission tomographyCortical brain areasIntra-class correlation coefficientRetest reproducibilityBrain areasBrain measuresHealthy human subjectsMean intra-class correlation coefficientOutcome measuresConstant infusionParent tracerBlood measurementsEmission tomographyNeuropsychiatric disordersPET measuresReceptorsHuman subjectsPET acquisitionMean intraEquilibrium imagingImaging methodInfusionBolusRT
2000
Myocardial blood-flow response during mental stress in patients with coronary artery disease
Arrighi J, Burg M, Cohen I, Kao A, Pfau S, Caulin-Glaser T, Zaret B, Soufer R. Myocardial blood-flow response during mental stress in patients with coronary artery disease. The Lancet 2000, 356: 310-311. PMID: 11071190, DOI: 10.1016/s0140-6736(00)02510-1.Peer-Reviewed Original Research
1999
Quantitation of benzodiazepine receptor binding with PET [11C]iomazenil and SPECT [123I]iomazenil: preliminary results of a direct comparison in healthy human subjects
Bremner J, Baldwin R, Horti A, Staib L, Ng C, Tan P, Zea-Ponce Y, Zoghbi S, Seibyl J, Soufer R, Charney D, Innis R. Quantitation of benzodiazepine receptor binding with PET [11C]iomazenil and SPECT [123I]iomazenil: preliminary results of a direct comparison in healthy human subjects. Psychiatry Research 1999, 91: 79-91. PMID: 10515463, DOI: 10.1016/s0925-4927(99)00015-3.Peer-Reviewed Original ResearchConceptsPositron emission tomographyBenzodiazepine receptorsArterial blood samplesBenzodiazepine receptor bindingHealthy human subjectsHuman subjectsNeuroreceptor bindingSingle photon emissionSingle bolusOccipital cortexBlood samplesTemporal cortexEmission tomographyBrain compartmentsDynamic positron emission tomographyReceptor bindingSPECTSame human subjectsPhoton emissionCortexHuman brainRadioligandPreliminary findingsBrainReceptorsNeural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: a positron emission tomography study
Bremner J, Staib L, Kaloupek D, Southwick S, Soufer R, Charney D. Neural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: a positron emission tomography study. Biological Psychiatry 1999, 45: 806-816. PMID: 10202567, PMCID: PMC3233761, DOI: 10.1016/s0006-3223(98)00297-2.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderNon-PTSD subjectsBlood flowVietnam combat veteransCerebral blood flow responseStress disorderBlood flow responsePositron emission tomography studySymptoms of patientsCerebral blood flowSubcortical brain areasEmission tomography studiesCombat veteransMedial prefrontal cortexPositron emission tomographyInferior parietal cortexNeural correlatesVisuospatial processingPTSD subjectsPTSD patientsBrain areasLingual gyrusAnterior cingulatePosterior cingulateParietal cortex
1998
Cerebral cortical hyperactivation in response to mental stress in patients with coronary artery disease
Soufer R, Bremner J, Arrighi J, Cohen I, Zaret B, Burg M, Goldman-Rakic P. Cerebral cortical hyperactivation in response to mental stress in patients with coronary artery disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 6454-6459. PMID: 9600987, PMCID: PMC27794, DOI: 10.1073/pnas.95.11.6454.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseVisual association cortexSuperior frontal gyrusRight visual association cortexCAD patientsHealthy subjectsPositron emission tomographyMental stressAssociation cortexFrontal gyrusArtery diseaseMyocardial ischemiaAnterior cingulateCentral nervous system effectsCAD patient groupCerebral cortical responsePainless myocardial ischemiaNervous system effectsLeft parietal cortexInferior parietal lobuleMiddle temporal gyrusPatient groupSerial subtraction taskRight thalamusInferior frontal gyrusDevelopment and Reliability of a Method for Using Magnetic Resonance Imaging for the Definition of Regions of Interest for Positron Emission Tomography
Bremner JD, Bronen RA, De Erasquin G, Vermetten E, Staib LH, Ng CK, Soufer R, Charney DS, Innis RB. Development and Reliability of a Method for Using Magnetic Resonance Imaging for the Definition of Regions of Interest for Positron Emission Tomography. Molecular Imaging And Biology 1998, 1: 145-159. PMID: 14516589, DOI: 10.1016/s1095-0397(98)00015-6.Peer-Reviewed Original ResearchMagnetic resonance imagingPositron emission tomographyCoregistered magnetic resonance imagingResonance imagingBrain regionsEmission tomographyPoor anatomical resolutionAnatomical resolutionRegional metabolic rateBrain metabolic rateIntra-class correlation coefficientSuperior anatomical resolutionPET scansMRI scansMetabolic rateBrain scansPhysiologic informationAnatomical landmarksPET brain imagesReliable methodPets siteIndependent ratersScansImportant physiological informationStandard anatomical atlas
1997
Effect of left ventricular function on the assessment of myocardial viability by technectium-99m sestamibi and correlation with positron emission tomography in patients with healed myocardial infarcts or stable angina pectoris, or both
Arrighi J, Ng C, Dey H, Wackers F, Soufer R. Effect of left ventricular function on the assessment of myocardial viability by technectium-99m sestamibi and correlation with positron emission tomography in patients with healed myocardial infarcts or stable angina pectoris, or both. The American Journal Of Cardiology 1997, 80: 1007-1013. PMID: 9352969, DOI: 10.1016/s0002-9149(97)00594-8.Peer-Reviewed Original ResearchConceptsCoronary artery diseasePositron emission tomographyLV dysfunctionArtery diseaseGroup 2Myocardial viabilityGroup 1Ejection fractionModerate coronary artery diseaseEmission tomographyModerate LV dysfunctionSevere LV dysfunctionStable angina pectorisLV ejection fractionGlobal LV dysfunctionAccuracy of technetiumSingle photon emissionSemiquantitative SPECTVentricular dysfunctionViability detectionAngina pectorisVentricular functionReduced perfusionSestamibi SPECTMyocardial infarctPositron Emission Tomography Measurement of Cerebral Metabolic Correlates of Tryptophan Depletion—Induced Depressive Relapse
Bremner JD, Innis RB, Salomon RM, Staib LH, Ng CK, Miller HL, Bronen RA, Krystal JH, Duncan J, Rich D, Price LH, Malison R, Dey H, Soufer R, Charney DS. Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Tryptophan Depletion—Induced Depressive Relapse. JAMA Psychiatry 1997, 54: 364-374. PMID: 9107153, DOI: 10.1001/archpsyc.1997.01830160092012.Peer-Reviewed Original ResearchConceptsCerebral metabolic correlatesDepressive relapseBrain metabolismMajor depressionMiddle frontal gyrusOrbitofrontal cortexTryptophan depletionMetabolic correlatesPositron emission tomography scanningFrontal gyrusRelapse-prone patientsPathogenesis of depressionPositron emission tomography (PET) measurementsSerotonin reuptake inhibitorsSymptoms of patientsPositron emission tomographySingle photon emissionSpecific brain regionsDorsolateral prefrontal cortexReuptake inhibitorsPlasma tryptophanLimbic regionsCaudate nucleusDepressive symptomsPatientsRadiosynthesis and PET imaging of [N-methyl-11C]LY257327 as a tracer for 5-HT transporters
Zea-Ponce Y, Baldwin R, Stratton M, Al-Tikriti M, Soufer R, Schaus J, Innis R. Radiosynthesis and PET imaging of [N-methyl-11C]LY257327 as a tracer for 5-HT transporters. Nuclear Medicine And Biology 1997, 24: 251-254. PMID: 9228659, DOI: 10.1016/s0969-8051(97)00062-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCarrier ProteinsChromatography, High Pressure LiquidCitalopramFemaleIsotope LabelingMaleMembrane GlycoproteinsMembrane Transport ProteinsNerve Tissue ProteinsOvariectomyPapioParoxetinePiperazinesRadiopharmaceuticalsRatsRats, Sprague-DawleySelective Serotonin Reuptake InhibitorsSerotonin Plasma Membrane Transport ProteinsSpectrophotometry, UltravioletTetrahydronaphthalenesTomography, Emission-ComputedConceptsSelective serotonin reuptake inhibitor citalopramSerotonin reuptake inhibitor citalopramReuptake inhibitor citalopramHigh brain uptakeSame brain regionsPositron emission tomographySerotonergic areasBrain uptakeMin postinjectionNontarget ratioUseful agentBrain regionsEmission tomographyN-methylMCi/mumolPET imagingNonspecific uptakeVivo studiesPartial inhibitionRadiochemical purityRadioactivity concentrationThalamusStriatumSerotoninCitalopramPositron Emission Tomography Measurement of Cerebral Metabolic Correlates of Yohimbine Administration in Combat-Related Posttraumatic Stress Disorder
Bremner JD, Innis RB, Ng CK, Staib LH, Salomon RM, Bronen RA, Duncan J, Southwick SM, Krystal JH, Rich D, Zubal G, Dey H, Soufer R, Charney DS. Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Yohimbine Administration in Combat-Related Posttraumatic Stress Disorder. JAMA Psychiatry 1997, 54: 246-254. PMID: 9075465, DOI: 10.1001/archpsyc.1997.01830150070011.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAdministration of yohimbineNorepinephrine releaseHealthy subjectsHealthy age-matched control subjectsAge-matched control subjectsStress disorderDouble-blind fashionPositron emission tomography (PET) measurementsBrain metabolic responsesCerebral metabolic correlatesBrain norepinephrine releaseSymptoms of anxietyPositron emission tomographyBrain metabolismControl subjectsYohimbine administrationPreclinical studiesMetabolic correlatesCaudate nucleusPatientsYohimbineVietnam combat veteransEmission tomographyOrbitofrontal cortex
1995
Synthesis and PET imaging of the benzodiazepine receptor tracer [N-methyl-11C]iomazenil
Baldwin R, Horti A, Bremner J, Stratton M, Dannals R, Ravert H, Zea-Ponce Y, Ng C, Dey H, Soufer R, Charney D, Mazza S, Sparks R, Stubbs J, Innis R. Synthesis and PET imaging of the benzodiazepine receptor tracer [N-methyl-11C]iomazenil. Nuclear Medicine And Biology 1995, 22: 659-665. PMID: 7581177, DOI: 10.1016/0969-8051(94)00139-b.Peer-Reviewed Original ResearchConceptsHuman biodistribution dataUrinary bladder wallReceptor tracerHealthy human volunteersPositron emission tomographyBladder wallHigh doseBenzodiazepine receptorsTime-activity curvesUseful agentSPECT studiesEmission tomographyHuman volunteersBiodistribution dataAdult baboonsMCi/mumolPET imagingRadiation dosesN-methylEffective dose equivalentInjectionPurity 99MinCortexDoseComparison of sestamibi single-photon emission computed tomography with positron emission tomography for estimating left ventricular myocarclial viability
Soufer R, Dey H, Ng C, Zaret B. Comparison of sestamibi single-photon emission computed tomography with positron emission tomography for estimating left ventricular myocarclial viability. The American Journal Of Cardiology 1995, 75: 1214-1219. PMID: 7778542, DOI: 10.1016/s0002-9149(99)80765-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCoronary DiseaseDeoxyglucoseFluorine RadioisotopesFluorodeoxyglucose F18HumansMaleMiddle AgedMyocardial ContractionRadionuclide VentriculographyStroke VolumeTechnetium Tc 99m SestamibiTomography, Emission-ComputedTomography, Emission-Computed, Single-PhotonVentricular Function, LeftConceptsPositron emission tomographySestamibi single-photon emissionSingle photon emissionCoronary artery diseaseMyocardial viabilityInferior wallArtery diseaseEmission tomographyFDG positron emission tomographySubset of patientsRegional ejection fractionDiscordant segmentsNonviable segmentsEjection fractionMethoxyisobutyl isonitrileRadionuclide ventriculographySestamibi protocolBlood flowMyocardial segmentsPatientsViable segmentsFluorodeoxyglucoseMIBITomographyDisease