2024
Bone erosions and joint damage caused by chikungunya virus: a systematic review
Amaral J, Taylor P, Schoen R. Bone erosions and joint damage caused by chikungunya virus: a systematic review. Revista Da Sociedade Brasileira De Medicina Tropical 2024, 57: e00404-2024. PMID: 38597523, PMCID: PMC11000508, DOI: 10.1590/0037-8682-0433-2023.Peer-Reviewed Original ResearchConceptsChronic chikungunya arthritisChikungunya arthritisJoint damageRheumatoid arthritisJoint painDisease-modifying antirheumatic drug therapyBone erosionProgression of radiographic joint damageDisease-modifying antirheumatic drugsSystematic reviewAntirheumatic drug therapyAcute febrile illnessPersistent joint painSimilar to rheumatoid arthritisRadiographic joint damageChikungunya virusYears post-infectionChronic joint damagePrevent joint damageDisease-modifying therapiesJoint structural damageRheumatoid arthritis treatmentAntirheumatic drugsProspective studyChikungunya infection
2023
Extra-articular Manifestations of Chikungunya
de Oliveira J, Nogueira I, Amaral J, Campos L, Mendonça M, de Brito Ricarte M, de Góes Cavalcanti L, Schoen R. Extra-articular Manifestations of Chikungunya. Revista Da Sociedade Brasileira De Medicina Tropical 2023, 56: e0341-2023. PMID: 38088664, PMCID: PMC10706034, DOI: 10.1590/0037-8682-0341-2023.Peer-Reviewed Original ResearchConceptsExtra-articular manifestationsChikungunya feverAtypical illnessAcute interstitial nephritisAcute anterior uveitisMinority of patientsSelf-limiting conditionAnterior uveitisAbdominal painChronic arthritisCutaneous manifestationsInterstitial nephritisAtypical symptomsUnusual manifestationAtypical featuresTrue diagnosisNatural historyTropical diseasesManifestationsFurther studiesIllnessDiagnosisAffected systemMyocarditisUveitis
2022
Pathogenesis of chronic chikungunya arthritis: Resemblances and links with rheumatoid arthritis
Amaral J, Bingham C, Taylor P, Vilá L, Weinblatt M, Schoen R. Pathogenesis of chronic chikungunya arthritis: Resemblances and links with rheumatoid arthritis. Travel Medicine And Infectious Disease 2022, 52: 102534. PMID: 36549417, DOI: 10.1016/j.tmaid.2022.102534.Peer-Reviewed Original ResearchConceptsChronic chikungunya arthritisMesenchymal stem cellsJoint painChikungunya virusReactivation of dormant virusesMorphologically similar to fibroblastsChikungunya feverEpigenetic changesChronic joint painAcute febrile illnessChikungunya virus infectionSimilar to fibroblastsMaculopapular rashChikungunya arthritisDormant virusesFebrile illnessLatent infectionMultipotent cellsStem cellsHeterogeneous groupRheumatoid arthritisPathogenic hypothesisGroup of multipotent cellsPainPatients