2020
Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling
Israelow B, Song E, Mao T, Lu P, Meir A, Liu F, Alfajaro MM, Wei J, Dong H, Homer RJ, Ring A, Wilen CB, Iwasaki A. Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling. Journal Of Experimental Medicine 2020, 217: e20201241. PMID: 32750141, PMCID: PMC7401025, DOI: 10.1084/jem.20201241.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin-Converting Enzyme 2AnimalsBetacoronavirusCell Line, TumorCoronavirus InfectionsCOVID-19DependovirusDisease Models, AnimalFemaleHumansInflammationInterferon Type ILungMaleMiceMice, Inbred C57BLMice, TransgenicPandemicsParvoviridae InfectionsPeptidyl-Dipeptidase APneumonia, ViralSARS-CoV-2Signal TransductionVirus ReplicationConceptsSARS-CoV-2Type I interferonMouse modelI interferonRobust SARS-CoV-2 infectionSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2SARS-CoV-2 infectionRespiratory syndrome coronavirus 2SARS-CoV-2 replicationCOVID-19 patientsSyndrome coronavirus 2Patient-derived virusesSignificant fatality ratePathological findingsInflammatory rolePathological responseEnzyme 2Receptor angiotensinFatality rateVaccine developmentGenetic backgroundViral replicationCoronavirus diseaseMice
2008
Cutting Edge: Engagement of NKG2A on CD8+ Effector T Cells Limits Immunopathology in Influenza Pneumonia
Zhou J, Matsuoka M, Cantor H, Homer R, Enelow RI. Cutting Edge: Engagement of NKG2A on CD8+ Effector T Cells Limits Immunopathology in Influenza Pneumonia. The Journal Of Immunology 2008, 180: 25-29. PMID: 18096998, DOI: 10.4049/jimmunol.180.1.25.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigensCD8-Positive T-LymphocytesHistocompatibility Antigens Class IInfluenza A virusMiceMice, Inbred BALB CMice, Inbred C57BLNK Cell Lectin-Like Receptor Subfamily CNK Cell Lectin-Like Receptor Subfamily DOrthomyxoviridae InfectionsPneumonia, ViralReceptors, ImmunologicReceptors, Natural Killer CellConceptsInfluenza pneumoniaT cellsLung injuryTNF productionT cell-mediated clearanceQa-1bAg-specific CD8Considerable lung injurySevere influenza infectionCD94/NKG2AT cell Ag recognitionEffector cell recognitionLimit immunopathologyNKG2A blockadeAntiviral CD8Distal airwaysInfluenza infectionPulmonary pathologyTNF-alphaCD8Infectious virusAg recognitionImmunopathologyPneumoniaCell recognition