2014
Cathepsin E Promotes Pulmonary Emphysema via Mitochondrial Fission
Zhang X, Shan P, Homer R, Zhang Y, Petrache I, Mannam P, Lee PJ. Cathepsin E Promotes Pulmonary Emphysema via Mitochondrial Fission. American Journal Of Pathology 2014, 184: 2730-2741. PMID: 25239563, PMCID: PMC4188869, DOI: 10.1016/j.ajpath.2014.06.017.Peer-Reviewed Original ResearchConceptsActivation/apoptosisPulmonary emphysemaChronic obstructive pulmonary disease (COPD) lungsCigarette smoke-induced lung diseaseSmoke-induced lung diseaseChronic obstructive pulmonary diseaseDynamin-related protein 1Obstructive pulmonary diseaseProtein 1Mitochondrial fission protein dynamin-related protein 1Lung tissue sectionsCathepsin ENew therapeutic targetsAir space enlargementFission protein dynamin-related protein 1Pulmonary diseaseEmphysematous changesClinical entityLung diseaseMolecular mechanismsEmphysema developmentMitochondrial fissionLung parenchymaE miceLung elasticityCD4+CD25+FoxP3+ Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-β1 exposed murine lung
Peng X, Moore MW, Peng H, Sun H, Gan Y, Homer RJ, Herzog EL. CD4+CD25+FoxP3+ Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-β1 exposed murine lung. Frontiers In Pharmacology 2014, 5: 80. PMID: 24904415, PMCID: PMC4032896, DOI: 10.3389/fphar.2014.00080.Peer-Reviewed Original ResearchTGF-β1Lung fibrosisDepletion of TregsRole of TregsRegulatory T cellsMurine lung fibrosisHuman TGF-β1 geneFibroblast growth factor 9TGF-β1 signalingTGF-β1 geneGrowth factor 9Model of fibrosisRegulatory TregTreg quantityCD25 antibodyDoxycycline-inducible overexpressionPulmonary fibrosisNaïve CD4Fibrocyte recruitmentIL-1αFGF-9 expressionLung parenchymaT cellsTregsFibrocyte accumulationPulmonary Fibrosis
Murray L, Homer R, Gulati M, Herzog E. Pulmonary Fibrosis. 2014, 2636-2653. DOI: 10.1016/b978-0-12-386456-7.05307-7.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsInterstitial lung diseasePulmonary fibrosisLung fibrosisConnective tissue disease-related interstitial lung diseaseIdiopathic pulmonary fibrosisSalient clinical featuresDistinctive pathological featuresWound healing responseClinical featuresChronic injuryLung diseasePathological featuresCirculating BiomarkersInflammatory responseLung parenchymaCertain therapiesPathogenic mechanismsScar tissueClinical monitoringFibrosisHealing responseFatal natureGenetic formsDiseasePotential role
2010
Recent advances in pulmonary fibrosis: implications for scleroderma
Homer RJ, Herzog EL. Recent advances in pulmonary fibrosis: implications for scleroderma. Current Opinion In Rheumatology 2010, 22: 683-689. PMID: 20693906, DOI: 10.1097/bor.0b013e32833ddcc9.BooksConceptsPulmonary fibrosisEpithelial cell injuryCell injuryIdiopathic pulmonary fibrosisRole of lymphocytesAlternative macrophage activationPathogenesis of sclerodermaTranslational human studiesEpithelial-mesenchymal transitionEndoplasmic reticulum stressMost patientsSystemic sclerosisLung fibrosisLymphocyte functionEffective therapyLeading causeLung parenchymaFibrotic responseHuman studiesMacrophage activationScar tissueFibrosisPossible associationAnimal modelingPatients