2000
Renal citrate metabolism and urinary citrate excretion in the infant rat
Melnick J, Preisig P, Alpern R, Baum M. Renal citrate metabolism and urinary citrate excretion in the infant rat. Kidney International 2000, 57: 891-897. PMID: 10720942, PMCID: PMC4089854, DOI: 10.1046/j.1523-1755.2000.057003891.x.Peer-Reviewed Original ResearchConceptsUrinary citrate excretionHigher urinary citrateCitrate excretionInfant ratsAdult ratsUrinary citrateRenal citrate metabolismMitochondrial aconitase activityCreatinine ratioCitrate metabolismRenal excretionSame prevalenceRenal stonesTwofold higher concentrationLower plasmaATP citrate lyase activityProximal tubulesHigher plasmaMetabolic cagesRat kidneyRatsAdult levelsInfantsMaturational differencesExcretion
1998
Converting enzyme inhibition causes hypocitraturia independent of acidosis or hypokalemia
Melnick J, Preisig P, Haynes S, Pak C, Sakhaee K, Alpern R. Converting enzyme inhibition causes hypocitraturia independent of acidosis or hypokalemia. Kidney International 1998, 54: 1670-1674. PMID: 9844143, DOI: 10.1046/j.1523-1755.1998.00150.x.Peer-Reviewed Original ResearchConceptsUrinary citrate excretionCitrate excretionUrinary citrateMetabolic acidosisATP-citrate lyaseEffects of enalaprilRenal citrate metabolismUrine citrate concentrationRenal cortical tissueChronic metabolic acidosisProximal tubular cellsPlasma pHNa/H antiporterAngiotensin IIIntracellular acidosisEnalaprilTubular cellsCitrate lyaseHypokalemiaEnzyme inhibitorsATP citrate lyase activityAcidosisCortical tissueRatsCitrate metabolism
1992
Citraturic Response to Oral Citric Acid Load
Sakhaee K, Alpern R, Poindexter J, Pak C. Citraturic Response to Oral Citric Acid Load. Journal Of Urology 1992, 147: 975-976. PMID: 1552616, DOI: 10.1016/s0022-5347(17)37437-2.Peer-Reviewed Original ResearchConceptsAcid loadCitraturic responseUrinary citrateCarbon dioxide pressureSingle oral loadUrinary citrate excretionSingle oral doseSerum citrate concentrationAcid-base balanceCitraturic effectsOral loadVenous pHOral doseSerum electrolytesUrinary pHCitrate excretionNormal subjectsAlkali loadPotassium citrateSignificant differencesHoursTotal carbon dioxideCitrateExcretionCitrate concentration