1998
Dominant negative c-Src inhibits angiotensin II induced activation of NHE3 in OKP cells
Tsuganezawa H, Preisig P, Alpern R. Dominant negative c-Src inhibits angiotensin II induced activation of NHE3 in OKP cells. Kidney International 1998, 54: 394-398. PMID: 9690205, DOI: 10.1046/j.1523-1755.1998.00029.x.Peer-Reviewed Original ResearchConceptsNa/H antiporter activityAngiotensin IIOKP cellsInhibits angiotensin IIVascular smooth muscleTyrosine kinase inhibitorsC-SrcHerbimycin AAntiporter activityNa/H antiporterActivation of NHE3Smooth muscleProximal tubulesPotent stimulatorNHE3 activationRegulation of NHE3Key mediatorKinase inhibitorsClonal cell linesNHE3 activityAntiporter activationCyclic AMPCell linesNHE3Acidosis
1995
Na+/H+ antiporter (NHE-1 isoform) in cultured vascular smooth muscle from the spontaneously hypertensive rat
LaPointe M, Ye M, Moe O, Alpern R, Batlle D. Na+/H+ antiporter (NHE-1 isoform) in cultured vascular smooth muscle from the spontaneously hypertensive rat. Kidney International 1995, 47: 78-87. PMID: 7731174, DOI: 10.1038/ki.1995.9.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsCultured aortic vascular smooth muscle cellsWistar/Kyoto ratsAortic vascular smooth muscle cellsWKY ratsHypertensive ratsNominal absenceCultured vascular smooth muscleVascular smooth muscleSmooth muscle cellsCell acidificationRate of intracellularNormotensive controlsKyoto ratsNHE-1 isoformWKY cellsSmooth muscleSHRHigh functional activityRatsMuscle cellsThymidine incorporationPresence of HCO3Exchange activityHCO3-/CO2