1994
Effect of glucocorticoids on renal cortical NHE-3 and NHE-1 mRNA
Baum M, Moe OW, Gentry DL, Alpern RJ. Effect of glucocorticoids on renal cortical NHE-3 and NHE-1 mRNA. American Journal Of Physiology 1994, 267: f437-f442. PMID: 8092257, DOI: 10.1152/ajprenal.1994.267.3.f437.Peer-Reviewed Original ResearchConceptsNHE-3 mRNA abundanceProximal tubulesNHE-3NHE-1MRNA abundanceChronic systemic administrationAdministration of dexamethasoneEffects of glucocorticoidsProximal tubule acidificationNHE-1 mRNAUnits/minChronic dexamethasoneTubule acidificationAcute increaseAntiporter activitySystemic administrationGlucocorticoid deficiencyIntravenous administrationBicarbonate absorptionMicrograms/DexamethasoneAntiporter isoformsDexamethasone occursRenal brush-border membrane vesiclesAdministration
1992
Long-term activation of protein kinase c causes chronic Na/H antiporter stimulation in cultured proximal tubule cells.
Horie S, Moe O, Miller RT, Alpern RJ. Long-term activation of protein kinase c causes chronic Na/H antiporter stimulation in cultured proximal tubule cells. Journal Of Clinical Investigation 1992, 89: 365-372. PMID: 1310692, PMCID: PMC442861, DOI: 10.1172/jci115594.Peer-Reviewed Original ResearchConceptsNa/H antiporter activityProximal tubule cellsCultured proximal tubule cellsLong-term activationTubule cellsProtein kinase CShort-term activationDose-dependent increaseKinase CActivity 24 hActinomycin DAntiporter activityNa/H antiporterChronic conditionsTwo- to threefold increaseAcute increaseEffect of phorbolProtein kinase C activationChronic effectsTransient increaseMicroM cycloheximidePersistent increaseAlpha-PMAKinase C activationChronic regulator