1999
Detoxification of Methylglyoxal by the Nucleophilic Bidentate, Phenylacylthiazolium Bromide
Ferguson G, VanPatten S, Bucala R, Al-Abed Y. Detoxification of Methylglyoxal by the Nucleophilic Bidentate, Phenylacylthiazolium Bromide. Chemical Research In Toxicology 1999, 12: 617-622. PMID: 10409401, DOI: 10.1021/tx990007y.Peer-Reviewed Original ResearchConceptsEscherichia coli double mutantRapid cell deathE. coli cellsDetoxification of methylglyoxalExponential-phase cellsDouble mutantSensitive bacterial assayColi cellsCell deathPhase cellsE. coliLong-term complicationsPotassium channelsReactive dicarbonylsBacterial assaysDetoxificationEndogenous nucleophilesCellsMethylglyoxalTissue damage
1996
NMR characterization of structure, backbone dynamics, and glutathione binding of the human macrophage migration inhibitory factor (MIF)
Mühlhahn P, Czisch M, Georgescu J, Renner C, Ross A, Holak T, Bernhagen J, Bucala R. NMR characterization of structure, backbone dynamics, and glutathione binding of the human macrophage migration inhibitory factor (MIF). Protein Science 1996, 5: 2095-2103. PMID: 8897610, PMCID: PMC2143260, DOI: 10.1002/pro.5560051016.Peer-Reviewed Original Research
1986
Structure of lysine adducts with 16α-hydroxyestrone and cortisol
Bucala R, Ulrich P, Chait B, Bencsath F, Cerami A. Structure of lysine adducts with 16α-hydroxyestrone and cortisol. The Journal Of Steroid Biochemistry And Molecular Biology 1986, 25: 127-133. PMID: 3091937, DOI: 10.1016/0022-4731(86)90291-8.Peer-Reviewed Original ResearchMeSH KeywordsEstroneHydrocortisoneHydroxyestronesLysineMagnetic Resonance SpectroscopyMass SpectrometrySchiff BasesConceptsSchiff baseReduced Schiff baseStructure of lysineCovalent addition productsPresence of NaCNBH3Schiff base adductsHeyns rearrangementNucleophilic additionAddition productsBase adductsEpsilon-amino groupLysine derivativesStructural analysisAdductsLysine residuesReactionNaCNBH3MoietyCarbonylAminesCompoundsSynthesisMoleculesProductsLysine