2000
Peripheral blood fibrocytes: Mesenchymal precursor cells and the pathogenesis of fibrosis
Chesney J, Bucala R. Peripheral blood fibrocytes: Mesenchymal precursor cells and the pathogenesis of fibrosis. Current Rheumatology Reports 2000, 2: 501-505. PMID: 11123104, DOI: 10.1007/s11926-000-0027-5.Peer-Reviewed Original ResearchConceptsPeripheral blood fibrocytesBlood fibrocytesTissue injuryDistinct cell surface phenotypePersistent T-cell activationNaïve T cellsPathogenesis of fibrosisCell surface phenotypeT cell activationCognate immunityAutoimmune disordersConnective tissue cellsImmunohistochemical studyForeign antigensT cellsSurface phenotypeMesenchymal precursor cellsScar formationFibrotic tissueFibrocytesGrowth factorPrecursor cellsNovel populationMatrix depositionInjury
1999
Macrophage migration inhibitory factor in rheumatoid arthritis: Evidence of proinflammatory function and regulation by glucocorticoids
Leech M, Metz C, Hall P, Hutchinson P, Gianis K, Smith M, Weedon H, Holdsworth S, Bucala R, Morand E. Macrophage migration inhibitory factor in rheumatoid arthritis: Evidence of proinflammatory function and regulation by glucocorticoids. Arthritis & Rheumatism 1999, 42: 1601-1608. PMID: 10446857, DOI: 10.1002/1529-0131(199908)42:8<1601::aid-anr6>3.0.co;2-b.Peer-Reviewed Original ResearchMeSH KeywordsAgedArthritis, RheumatoidCells, CulturedCytokinesGlucocorticoidsHumansImmunohistochemistryInterferon-gammaLymphocyte ActivationMacrophage Migration-Inhibitory FactorsMacrophagesMonocytesReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSynovial MembraneT-LymphocytesTumor Necrosis Factor-alphaConceptsMacrophage migration inhibitory factorFibroblast-like synoviocytesRA fibroblast-like synoviocytesEnzyme-linked immunosorbent assayRheumatoid arthritisMigration inhibitory factorTNFalpha releaseExpression of MIFIntracellular macrophage migration inhibitory factorInhibitory factorCultured RA fibroblast-like synoviocytesCytokine macrophage migration inhibitory factorCultured fibroblast-like synoviocytesTumor necrosis factor-alpha synthesisHuman RA synoviumRA synovial tissueNecrosis factor-alpha synthesisHuman autoimmune diseasesPotential therapeutic targetTranscription-polymerase chain reactionMessenger RNA expressionT cell activationMIF expressionRA patientsRA synovium
1998
Macrophage migration inhibitory factor is a critical mediator of the activation of immune cells by exotoxins of Gram-positive bacteria
Calandra T, Spiegel L, Metz C, Bucala R. Macrophage migration inhibitory factor is a critical mediator of the activation of immune cells by exotoxins of Gram-positive bacteria. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 11383-11388. PMID: 9736745, PMCID: PMC21651, DOI: 10.1073/pnas.95.19.11383.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodiesBacterial ToxinsCell DivisionCells, CulturedDisease Models, AnimalEnterotoxinsExotoxinsGram-Positive BacteriaInflammationInterferon-gammaInterleukin-2Lymphocyte ActivationMacrophage Migration-Inhibitory FactorsMacrophages, PeritonealMicePituitary GlandShock, SepticSpleenStaphylococcusStreptococcusSuperantigensConceptsMacrophage migration inhibitory factorMigration inhibitory factorMIF secretionInhibitory factorStaphylococcal toxic shock syndrome toxin 1Toxic shock syndrome toxin-1Anti-MIF antibodiesSplenocyte cytokine productionTSST-1 injectionInterferon-gamma secretionLethal mouse modelStreptococcal pyrogenic exotoxinT cell cytokinesInnate host responseLethal toxic shockProliferation of splenocytesT-cell productsInnate immune responseSyndrome toxin-1Dose-response studyMouse peritoneal macrophagesSpleen enlargementMIF antibodyC57BL/6 miceCytokine production
1997
The peripheral blood fibrocyte is a potent antigen-presenting cell capable of priming naive T cells in situ
Chesney J, Bacher M, Bender A, Bucala R. The peripheral blood fibrocyte is a potent antigen-presenting cell capable of priming naive T cells in situ. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 6307-6312. PMID: 9177213, PMCID: PMC21045, DOI: 10.1073/pnas.94.12.6307.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen-Presenting CellsAntigens, CDCell DifferentiationCell MovementCells, CulturedCicatrixCoculture TechniquesCrosses, GeneticFemaleFibroblastsFlow CytometryHIVHIV Core Protein p24HIV Envelope Protein gp120HLA-DR AntigensHumansImmunophenotypingLymphocyte ActivationMaleMiceMice, Inbred BALB CMice, Inbred C3HMice, Inbred DBANeutralization TestsSkinT-LymphocytesConceptsNaive T cellsAntigen presentationT cellsHuman fibrocytesDistinct cell surface phenotypePrime naive T cellsPotent antigen-presenting cellsMajor histocompatability complex (MHC) moleculesAdhesion molecules CD11aAntigen-specific immunityProximal lymph nodesPeripheral blood fibrocytesAntigen-presenting cellsCostimulatory molecules CD80T cell proliferationCell surface phenotypeBlood-borne cellsHIV protein p24Dendritic cellsLymph nodesBlood fibrocytesPotent APCsTissue injurySurface phenotypeCutaneous injury