1996
What is the effect of hyperglycemia on atherogenesis and can it be reversed by aminoguanidine?
Bucala R. What is the effect of hyperglycemia on atherogenesis and can it be reversed by aminoguanidine? Diabetes Research And Clinical Practice 1996, 30: s123-s130. PMID: 8964186, DOI: 10.1016/s0168-8227(96)80048-9.Peer-Reviewed Original ResearchConceptsDiabetic patientsLDL levelsEndothelium-derived relaxing factorsElevated LDL levelsEffects of hyperglycemiaLow-density lipoproteinRelaxing factorsVascular diseaseVascular pathologyVascular permeabilityNormal controlsClinical observationsAdvanced glycosylationLipoprotein depositionVascular wallELISA techniqueClearance mechanismsNitric oxideClearance kineticsPatientsELISA analysisLDLAgeAminoguanidineLipoprotein
1995
A Role for DNA Mutations in Diabetes-Associated Teratogenesis in Transgenic Embryos
Lee A, Plump A, DeSimone C, Cerami A, Bucala R. A Role for DNA Mutations in Diabetes-Associated Teratogenesis in Transgenic Embryos. Diabetes 1995, 44: 20-24. PMID: 7813809, DOI: 10.2337/diab.44.1.20.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBlood GlucoseCongenital AbnormalitiesDiabetes Mellitus, ExperimentalDNAEmbryo, MammalianEmbryonic and Fetal DevelopmentFemaleHyperglycemiaLac OperonMaleMiceMice, TransgenicMolecular Sequence DataPolymerase Chain ReactionPregnancyPregnancy in DiabeticsConceptsDNA mutationsDiabetic environmentInsulin-dependent diabetic mothersMaternal diabetic environmentTransgenic mouse model systemCause of deathMouse model systemTransgenic embryosEmbryonic developmentTarget genesDiabetic mothersFetal malformationsGestational periodNormoglycemic conditionsCongenital malformationsHyperglycemic environmentDiabetic embryopathyFirst direct evidenceMutation frequencyModel systemGenotoxic effectsDiabetesMutant frequencyMalformationsTwofold increase