1998
Involvement of macrophage migration inhibitory factor in the evolution of rat adjuvant arthritis
Leech M, Metz C, Santos L, Peng T, Holdsworth S, Bucala R, Morand E. Involvement of macrophage migration inhibitory factor in the evolution of rat adjuvant arthritis. Arthritis & Rheumatism 1998, 41: 910-917. PMID: 9588744, DOI: 10.1002/1529-0131(199805)41:5<910::aid-art19>3.0.co;2-e.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalArthritis, ExperimentalBlotting, WesternCell CountCells, CulturedDose-Response Relationship, DrugEdemaEnzyme-Linked Immunosorbent AssayImmunohistochemistryMacrophage Migration-Inhibitory FactorsMacrophagesMaleNeutralization TestsRatsRats, Sprague-DawleySynovial MembraneConceptsMacrophage migration inhibitory factorRat adjuvant arthritisAdjuvant arthritisMigration inhibitory factorSynovial macrophagesRat synoviumLevels of MIFRole of MIFInhibitory factorMonoclonal antibodiesArthritis clinical scoresT cell accumulationDose-dependent inhibitionEnzyme-linked immunosorbentMIF treatmentAdjuvant injectionMAb treatmentClinical scoresED-1Leukocyte numbersSpecific monoclonal antibodiesClinical aspectsT cellsArthritisMacrophage activation
1995
An Inhibitor of Macrophage Arginine Transport and Nitric Oxide Production (CNI-1493) Prevents Acute Inflammation and Endotoxin Lethality
Bianchi M, Ulrich P, Bloom O, Meistrell M, Zimmerman G, Schmidtmayerova H, Bukrinsky M, Donnelley T, Bucala R, Sherry B, Manogue K, Tortolani A, Cerami A, Tracey K. An Inhibitor of Macrophage Arginine Transport and Nitric Oxide Production (CNI-1493) Prevents Acute Inflammation and Endotoxin Lethality. Molecular Medicine 1995, 1: 254-266. PMID: 8529104, PMCID: PMC2229913, DOI: 10.1007/bf03401550.Peer-Reviewed Original ResearchConceptsNitric oxide synthaseL-arginine transportNO productionInflammatory responseBlood vesselsEndotoxin lethalityEDRF activityL-arginineArginine transportInhibitor of NOSLethal LPS challengeSystemic inflammatory responseNitric oxide productionSelective inhibitorDevelopment of carrageenanProduction of NOBackgroundNitric oxideEDRF responseMurine macrophage-like cell lineTetravalent guanylhydrazoneFootpad inflammationImportant homeostatic mechanismAcute inflammationLPS challengeMacrophage-like cell line