2001
Characterization of a Novel Hemoglobin-Glutathione Adduct That Is Elevated in Diabetic Patients
Al-Abed Y, VanPatten S, Li H, Lawson J, FitzGerald G, Manogue K, Bucala R. Characterization of a Novel Hemoglobin-Glutathione Adduct That Is Elevated in Diabetic Patients. Molecular Medicine 2001, 7: 619-623. PMID: 11778651, PMCID: PMC1950073, DOI: 10.1007/bf03401868.Peer-Reviewed Original ResearchConceptsDiabetic patientsDiabetes mellitusPredictor of prognosisBlood glucose levelsNormal patientsGlucose levelsPatientsUseful markerNormal individualsPathologic situationsOxidative stressMellitusAdditional markersΒ-globin chainsLiquid chromatography-mass spectroscopyΒ-chainMarkersHigh levelsPrognosisDiseaseDiagnosis
1996
An agent cleaving glucose-derived protein crosslinks in vitro and in vivo
Vasan S, Zhang X, Zhang X, Kapurniotu A, Bernhagen J, Teichberg S, Basgen J, Wagle D, Shih D, Terlecky I, Bucala R, Cerami A, Egan J, Ulrich P. An agent cleaving glucose-derived protein crosslinks in vitro and in vivo. Nature 1996, 382: 275-278. PMID: 8717046, DOI: 10.1038/382275a0.Peer-Reviewed Original ResearchConceptsAGE crosslinksAdvanced glycation pathwayLow-density lipoproteinPotential therapeutic approachPotential pharmacological strategiesFormation of AGEsReactive α-dicarbonylsPharmacological strategiesGlycation pathwayTherapeutic approachesAdvanced glycationNon-enzymatic glycosylationCollagen crosslinkingNormal agingN-phenacylthiazolium bromideConnective tissueCellular receptorsAgeGlycationTissueProtein crosslinksPost-translational modification processMatrix componentsVivo pointAccelerated rate
1992
Advanced Glycosylation: Chemistry, Biology, and Implications for Diabetes and Aging
Bucala R, Cerami A. Advanced Glycosylation: Chemistry, Biology, and Implications for Diabetes and Aging. Advances In Pharmacology 1992, 23: 1-34. PMID: 1540533, DOI: 10.1016/s1054-3589(08)60961-8.Peer-Reviewed Original ResearchConceptsBiological processesGlycosylation processGlycosylation mechanismsBiochemical basisRelated pathwaysAge-related processesBiologyPathological processesGlycosylation productsDiverse effectsStructural elucidationAdvanced glycosylation productsCell-mediated processGlycosylationInsightsPathwayBiochemistryElucidationMaillard reactionAccumulationVivoLarge partMultiorgan pathology