Insulin secretion is regulated by the glucose-dependent production of islet β cell macrophage migration inhibitory factor
Waeber G, Calandra T, Roduit R, Haefliger J, Bonny C, Thompson N, Thorens B, Temler E, Meinhardt A, Bacher M, Metz C, Nicod P, Bucala R. Insulin secretion is regulated by the glucose-dependent production of islet β cell macrophage migration inhibitory factor. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 4782-4787. PMID: 9114069, PMCID: PMC20802, DOI: 10.1073/pnas.94.9.4782.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMigration inhibitory factorInsulin releaseInsulin secretionBeta cellsRecombinant macrophage migration inhibitory factorInhibitory factorGlucose-induced insulin releasePancreatic islet beta cellsInsulin-secreting beta cellsINS-1 cell lineIslet beta cellsIsolated rat isletsInsulin secretion responseIslets of LangerhansConcentration-dependent mannerIslet cell productsImmune cellsT lymphocytesPituitary hormonesPerifusion studiesAutocrine fashionRat isletsSecretion responseGlucocorticoid stimulation