1999
Sequencing of Genomic DNA
Mahlknecht U, Hoelzer D, Bucala R. Sequencing of Genomic DNA. BioTechniques 1999, 27: 406-408. PMID: 10489593, DOI: 10.2144/99273bm01.Peer-Reviewed Original ResearchCloning and Characterization of the Murine Histone Deacetylase (HDAC3)
Mahlknecht U, Hoelzer D, Bucala R, Verdin E. Cloning and Characterization of the Murine Histone Deacetylase (HDAC3). Biochemical And Biophysical Research Communications 1999, 263: 482-490. PMID: 10491319, DOI: 10.1006/bbrc.1999.1389.Peer-Reviewed Original ResearchConceptsHistone deacetylasesCore histone proteinsHuman chromosome 5q31Potential tumor suppressor geneHistone acetylation modifiersMalignant myeloid diseasesTumor suppressor geneHistone proteinsTranscriptional complexHistone acetylationDevelopment of cancerHistone deacetylaseSuppressor geneHDAC3Chromosome 5q31Cellular proliferationEnzymatic activityAcetylationMyeloid diseasesImportant insightsOrthologsHistonesCloningDeacetylasesGenes
1997
Molecular Characterization of a Mouse Genomic Element Mobilized by Advanced Glycation Endproduct Modified-DNA (AGE-DNA)
Pushkarsky T, Rourke L, Spiegel L, Seldin M, Bucala R. Molecular Characterization of a Mouse Genomic Element Mobilized by Advanced Glycation Endproduct Modified-DNA (AGE-DNA). Molecular Medicine 1997, 3: 740-749. PMID: 9407550, PMCID: PMC2230240, DOI: 10.1007/bf03401712.Peer-Reviewed Original Research
1995
A Role for DNA Mutations in Diabetes-Associated Teratogenesis in Transgenic Embryos
Lee A, Plump A, DeSimone C, Cerami A, Bucala R. A Role for DNA Mutations in Diabetes-Associated Teratogenesis in Transgenic Embryos. Diabetes 1995, 44: 20-24. PMID: 7813809, DOI: 10.2337/diab.44.1.20.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBlood GlucoseCongenital AbnormalitiesDiabetes Mellitus, ExperimentalDNAEmbryo, MammalianEmbryonic and Fetal DevelopmentFemaleHyperglycemiaLac OperonMaleMiceMice, TransgenicMolecular Sequence DataPolymerase Chain ReactionPregnancyPregnancy in DiabeticsConceptsDNA mutationsDiabetic environmentInsulin-dependent diabetic mothersMaternal diabetic environmentTransgenic mouse model systemCause of deathMouse model systemTransgenic embryosEmbryonic developmentTarget genesDiabetic mothersFetal malformationsGestational periodNormoglycemic conditionsCongenital malformationsHyperglycemic environmentDiabetic embryopathyFirst direct evidenceMutation frequencyModel systemGenotoxic effectsDiabetesMutant frequencyMalformationsTwofold increase
1994
Differential expression of the small inducible cytokines GRO α and GROβ by synovial fibroblasts in chronic arthritis: Possible role in growth regulation
Hogan M, Sherry B, Ritchlin C, Fabre M, Winchester R, Cerami A, Bucala R. Differential expression of the small inducible cytokines GRO α and GROβ by synovial fibroblasts in chronic arthritis: Possible role in growth regulation. Cytokine 1994, 6: 61-69. PMID: 8003635, DOI: 10.1016/1043-4666(94)90009-4.Peer-Reviewed Original ResearchMeSH KeywordsActinsArthritis, RheumatoidBase SequenceCells, CulturedChemokine CXCL1Chemokines, CXCChemotactic FactorsConsensus SequenceCytokinesDNA PrimersFibroblastsGene ExpressionGrowth SubstancesHumansIntercellular Signaling Peptides and ProteinsInterleukin-8Molecular Sequence DataPolymerase Chain ReactionRNA, MessengerSulfur RadioisotopesSynovial MembraneTranscription, GeneticConceptsSynovial fibroblastsGRO alphaChronic arthritisRheumatoid synoviaSynovial fibroblast cell lineGRO betaPro-inflammatory statePro-inflammatory activityRheumatoid arthritisChronic inflammationConnective tissue responseRheumatoid synoviumInflammatory cytokinesRate of proliferationSynovial pannusCytokine activationGRO gammaMetalloproteinase activityArthritisSynoviaGrowth factorConstitutive expressionGrowth dysregulationTissue responseCell lines