2022
Macrophage Migration Inhibitory Factor (MIF) Promotes Increased Proportions of the Highly Permissive Th17-like Cell Profile during HIV Infection
Trifone C, Baquero L, Czernikier A, Benencio P, Leng L, Laufer N, Quiroga MF, Bucala R, Ghiglione Y, Turk G. Macrophage Migration Inhibitory Factor (MIF) Promotes Increased Proportions of the Highly Permissive Th17-like Cell Profile during HIV Infection. Viruses 2022, 14: 2218. PMID: 36298774, PMCID: PMC9611675, DOI: 10.3390/v14102218.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMIF stimulationMIF treatmentIL-17AHIV infectionMIF/CD74 axisFounder HIV-1Functionality of CD4Higher IL-17AHigher MIF concentrationsMIF plasma levelsHIV-1 infectionMigration inhibitory factorPossible therapeutic targetMIF concentrationsIntracellular cytokinesR5-tropicCytokine productionIL-1βIL-6IL-8Plasma levelsHealthy donorsViral persistenceT lymphocytes
1998
MIF Expression in the Rat Brain: Implications for Neuronal Function
Bacher M, Meinhardt A, Lan H, Dhabhar F, Mu W, Metz C, Chesney J, Gemsa D, Donnelly T, Atkins R, Bucala R. MIF Expression in the Rat Brain: Implications for Neuronal Function. Molecular Medicine 1998, 4: 217-230. PMID: 9606175, PMCID: PMC2230367, DOI: 10.1007/bf03401919.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMIF mRNA expressionMIF expressionMIF mRNAMIF immunoreactivityMIF proteinGlucocorticoid actionRecombinant macrophage migration inhibitory factorNeuroendocrine systemMRNA expressionSystemic inflammatory responseInflammatory stress responseMigration inhibitory factorCerebrospinal fluid contentAnterior pituitary glandMonocytes/macrophagesTNF-α proteinHippocampal CA3 fieldTotal brain RNAProinflammatory factorsMIF antibodySitu hybridizationIntracisternal injectionBaseline expression patternCytokine production