2001
Up-regulation of macrophage migration inhibitory factor in acute renal allograft rejection in the rat
Brown F, Nikolic-Paterson D, Metz C, Bucala R, Atkins R, Lan H. Up-regulation of macrophage migration inhibitory factor in acute renal allograft rejection in the rat. Clinical & Experimental Immunology 2001, 118: 329-336. PMID: 10540199, PMCID: PMC1905421, DOI: 10.1046/j.1365-2249.1999.01048.x.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMIF mRNA expressionAcute renal allograft rejectionAcute allograft rejectionRenal allograft rejectionAllograft rejectionMigration inhibitory factorDay 5MIF expressionRenal allograftsMRNA expressionDay 1Inhibitory factorLocal MIF productionMIF protein expressionNormal renal functionT-cell infiltratesCell-mediated diseaseSevere tubular damageCellular immune responsesImmune cell-mediated diseasesSevere tubulitisSevere rejectionCreatinine clearanceMIF production
2000
Expression of macrophage migration inhibitory factor in human glomerulonephritis
Lan H, Yang N, Nikolic-Paterson D, Yu X, Mu W, Isbel N, Metz C, Bucala R, Atkins R. Expression of macrophage migration inhibitory factor in human glomerulonephritis. Kidney International 2000, 57: 499-509. PMID: 10652026, DOI: 10.1046/j.1523-1755.2000.00869.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBiopsyCohort StudiesEpithelial CellsFemaleGene ExpressionGlomerulonephritis, MembranoproliferativeGlomerulonephritis, MembranousHumansIn Situ HybridizationKidney GlomerulusMacrophage Migration-Inhibitory FactorsMacrophagesMaleMiddle AgedReference ValuesRNA, MessengerT-LymphocytesConceptsMacrophage migration inhibitory factorMIF expressionMigration inhibitory factorFocal segmental glomerulosclerosisHuman glomerulonephritisProliferative formsMIF mRNAPathogenic roleExperimental glomerulonephritisInhibitory factorProgressive formRenal MIF expressionRenal function impairmentT cell accumulationT-cell infiltratesEpithelial cellsMinimal change diseaseFocal segmental lesionsGlomerular endothelial cellsTubular epithelial cellsNormal human kidneyAttractive therapeutic targetCreatinine clearanceGlomerular epithelial cellsLupus nephritis