GENE-26. HOST GENETIC VARIATIONS IN MACROPHAGE MIGRATION INHIBITOR FACTOR CONFER WORSE PROGNOSIS IN GLIOBLASTOMA
Otvos B, Grabowski M, Alban T, Golubovsky J, Neumann C, Rabjlenovic A, Bayik D, Lauko A, Bucala R, Vogelbaum M, Lathia J. GENE-26. HOST GENETIC VARIATIONS IN MACROPHAGE MIGRATION INHIBITOR FACTOR CONFER WORSE PROGNOSIS IN GLIOBLASTOMA. Neuro-Oncology 2019, 21: vi103-vi103. PMCID: PMC6847914, DOI: 10.1093/neuonc/noz175.428.Peer-Reviewed Original ResearchProgression-free survivalShorter progression-free survivalMacrophage migration inhibitory factorOverall survivalGBM patientsMIF expressionSingle nucleotide polymorphismsRisk factorsSNP statusGBM developmentKarnofsky performance statusWorse overall prognosisShorter overall survivalImmune suppressive microenvironmentMigration inhibitory factorGBM cancer stem cellsCancer stem cellsMGMT methylation statusGenomic risk factorsFree survivalOverall prognosisPerformance statusSuppressor cellsCare therapyPrognostic factorsIMMU-28. TARGETING IMMUNOSUPPRESSIVE MYELOID DERIVED SUPPRESSOR CELLS VIA MIF/CD74 SIGNALING AXIS TO ATTENUATE GBM GROWTH
Alban T, Bayik D, Otvos B, Grabowski M, Ahluwalia M, Bucala R, Vogelbaum M, Lathia J. IMMU-28. TARGETING IMMUNOSUPPRESSIVE MYELOID DERIVED SUPPRESSOR CELLS VIA MIF/CD74 SIGNALING AXIS TO ATTENUATE GBM GROWTH. Neuro-Oncology 2019, 21: vi125-vi125. PMCID: PMC6847354, DOI: 10.1093/neuonc/noz175.521.Peer-Reviewed Original ResearchMacrophage migration inhibitory factorTumor growthTumor microenvironmentMIF receptorM-MDSCsCytokine macrophage migration inhibitory factorGeneration of MDSCsTumor-infiltrating MDSCsMigration inhibitory factorMCP-1 secretionPersistent tumor growthImmune cell recognitionFuture clinical assessmentImmunosuppressive myeloidMDSC generationMDSC inhibitionMonocytic MDSCsPotent immunosuppressionMDSC functionSuppressor cellsImmunosuppressive microenvironmentImmune suppressionPoor prognosisImmune cellsCo-culture system