2023
Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation
Pekayvaz K, Gold C, Hoseinpour P, Engel A, Martinez-Navarro A, Eivers L, Coletti R, Joppich M, Dionísio F, Kaiser R, Tomas L, Janjic A, Knott M, Mehari F, Polewka V, Kirschner M, Boda A, Nicolai L, Schulz H, Titova A, Kilani B, Lorenz M, Fingerle-Rowson G, Bucala R, Enard W, Zimmer R, Weber C, Libby P, Schulz C, Massberg S, Stark K. Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation. Immunity 2023, 56: 2325-2341.e15. PMID: 37652021, PMCID: PMC10588993, DOI: 10.1016/j.immuni.2023.08.002.Peer-Reviewed Original ResearchChronic inflammationVascular macrophagesPersistent tissue injuryChronic inflammatory diseaseSmooth muscle cellsMacrophage nicheInflammation contributesChemokine CCL2Inflammatory diseasesPlaque areaTissue injuryVascular bedPlaque necrosisMacrophage phenotypeAdvanced stageHomeostatic functionsNecrotic coreMuscle cellsInflammationAtherosclerosisMacrophagesMural cellsIntravital imagingProtective nicheNecrotic cells
2018
4148Activation of canonical proinflammatory pathways in smooth muscle cells exerts paradoxical atheroprotective effects
Stark K, Pekayvaz K, Hoseinpour P, Coletti R, Gold C, Ishikawa-Ankerhold H, Lorenz M, Fingerle-Rowson G, Bucala R, Schulz C, Massberg S. 4148Activation of canonical proinflammatory pathways in smooth muscle cells exerts paradoxical atheroprotective effects. European Heart Journal 2018, 39: ehy563.4148. DOI: 10.1093/eurheartj/ehy563.4148.Peer-Reviewed Original Research
2000
De Novo Expression of Macrophage Migration Inhibitory Factor in Atherogenesis in Rabbits
Lin S, Yu X, Chen Y, Huang X, Metz C, Bucala R, Lau C, Lan H. De Novo Expression of Macrophage Migration Inhibitory Factor in Atherogenesis in Rabbits. Circulation Research 2000, 87: 1202-1208. PMID: 11110779, DOI: 10.1161/01.res.87.12.1202.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorUpregulation of MIFSmooth muscle cellsVascular endothelial cellsMIF expressionMigration inhibitory factorFatty streak lesion formationInhibitory factorAbility of MIFIntercellular adhesion molecule-1 expressionAdhesion molecule-1 expressionFoam cell-rich lesionsNew Zealand white rabbitsAccumulation of macrophagesMolecule-1 expressionTranscriptase-polymerase chain reactionHypercholesterolemic rabbit modelEarly fatty streaksZealand white rabbitsDe novo expressionMacrophage-mediated diseasesMIF levelsCholesterol dietMIF mRNANormal diet
1997
Elevated AGE-Modified ApoB in Sera of Euglycemic, Normolipidemic Patients with Atherosclerosis: Relationship to Tissue AGEs
Stitt A, He C, Friedman S, Scher L, Rossi P, Ong L, Founds H, Li Y, Bucala R, Vlassara H. Elevated AGE-Modified ApoB in Sera of Euglycemic, Normolipidemic Patients with Atherosclerosis: Relationship to Tissue AGEs. Molecular Medicine 1997, 3: 617-627. PMID: 9323713, PMCID: PMC2230092, DOI: 10.1007/bf03401819.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAgingApolipoproteins BArteriosclerosisCarotid ArteriesCollagenEndothelium, VascularEnzyme-Linked Immunosorbent AssayFemaleGlycation End Products, AdvancedHumansImmunohistochemistryMacrophagesMaleMicroscopy, FluorescenceMiddle AgedReceptor for Advanced Glycation End ProductsReceptors, ImmunologicRegression AnalysisConceptsSmooth muscle cellsAGE-specific receptorsMononuclear cellsAtherosclerotic vascular diseaseOcclusive atherosclerotic diseaseDevelopment of hyperlipidemiaLipid-laden macrophagesYoung healthy personsEarly-stage lesionsCardiac bypass patientsAGE-R1Nondiabetic patientsAsymptomatic patientsAsymptomatic personsBypass patientsNormolipidemic patientsAtherosclerotic diseaseDistribution of ageVascular diseaseInflammatory responseLate-stage plaquesAtheromatous lesionsEarly lesionsFatty streaksNondiabetic etiology