2009
Macrophage migration inhibitory factor and multiple organ dysfunction syndrome
Yende S, Angus D, Bucala R. Macrophage migration inhibitory factor and multiple organ dysfunction syndrome. Journal Of Organ Dysfunction 2009, 5: 10-16. DOI: 10.1080/17471060802443653.Peer-Reviewed Original ResearchMacrophage migration inhibitory factorMigration inhibitory factorSevere sepsisOrgan dysfunctionInhibitory factorMultiple organ dysfunction syndromeOrgan dysfunction syndromeInnate immune responseDysfunction syndromePoor outcomeCertain infectionsImmune responseHuman studiesSepsisDetrimental roleKey mediatorDysfunctionImportant predictorCritical roleDetrimental effectsGlucocorticoidsSyndromeInfection
2000
Protection from septic shock by neutralization of macrophage migration inhibitory factor
Calandra T, Echtenacher B, Roy D, Pugin J, Metz C, Hültner L, Heumann D, Männel D, Bucala R, Glauser M. Protection from septic shock by neutralization of macrophage migration inhibitory factor. Nature Medicine 2000, 6: 164-170. PMID: 10655104, DOI: 10.1038/72262.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorSeptic shockMigration inhibitory factorLethal peritonitisSevere sepsisMIF antibodyRecombinant macrophage migration inhibitory factorAnti-tumor necrosis factorInhibitory factorTNFα knockout micePathogenesis of sepsisPlasma of patientsNew therapeutic targetsBacterial peritonitisIll patientsInvestigational therapiesCecal ligationNecrosis factorNormal micePivotal cytokineSystemic circulationKnockout miceTherapeutic targetSepsisPeritonitis