Neutralization of Macrophage Migration Inhibitory Factor (MIF) Reduces GVHD but Preserves GVL.
Miklos S, Mueller G, Lindner P, Chang Y, Holler E, Bucala R, Hildebrandt G. Neutralization of Macrophage Migration Inhibitory Factor (MIF) Reduces GVHD but Preserves GVL. Blood 2007, 110: 3234. DOI: 10.1182/blood.v110.11.3234.3234.Peer-Reviewed Original ResearchMacrophage migration inhibitory factorMigration inhibitory factorAllo-SCTT cell activationClinical GVHDCell activationInhibitory factorWeight lossSeverity of GVHDTime of transplantationClinical scoring systemInflammatory cytokine secretionHalf of animalsT cell proliferationMouse macrophage migration inhibitory factorP815 tumor cellsTumor cell eliminationAcute graftHost diseaseSystemic inflammationMajor complicationsTNFα levelsSerum IFNγCell transplantationInflammatory cytokines