2021
MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model
Tilstam PV, Schulte W, Holowka T, Kim BS, Nouws J, Sauler M, Piecychna M, Pantouris G, Lolis E, Leng L, Bernhagen J, Fingerle-Rowson G, Bucala R. MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model. Journal Of Clinical Investigation 2021, 131: e127171. PMID: 34850744, PMCID: PMC8631602, DOI: 10.1172/jci127171.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCytokinesDisease Models, AnimalFemaleFlow CytometryGene Expression ProfilingInflammationIntramolecular OxidoreductasesLeukocyte CountMacrophage Migration-Inhibitory FactorsMacrophagesMacrophages, PeritonealMaleMiceMice, Inbred C57BLMice, TransgenicPeritoneal LavagePhenotypeProtein BindingRNA-SeqSepsisSignal TransductionConceptsMacrophage migration inhibitory factorSmall peritoneal macrophagesLarge peritoneal macrophagesPolymicrobial sepsisPeritoneal macrophagesMIF receptor CD74MIF promoter polymorphismsMIF-2Migration inhibitory factorPolymicrobial sepsis modelMIF deficiencyAdoptive transferSeptic shockSurvival benefitInfectious insultsMIF antibodyExcessive inflammationInflammatory cytokinesReceptor CD74Sepsis modelProtective effectPeritoneal cavityDifferent infectionsPromoter polymorphismInflammatory macrophages
2019
2598. Macrophage Migration Inhibitory Factor May Contribute to Disseminated Coccidioidomycosis Susceptibility
Odio C, Leng L, Siu E, Piecychna M, Galgiani J, Holland S, Bucala R. 2598. Macrophage Migration Inhibitory Factor May Contribute to Disseminated Coccidioidomycosis Susceptibility. Open Forum Infectious Diseases 2019, 6: s903-s903. PMCID: PMC6810323, DOI: 10.1093/ofid/ofz360.2276.Peer-Reviewed Original ResearchMacrophage migration inhibitory factorPlasma MIF levelsHigh MIF expressionMigration inhibitory factorHuman lung epithelial cellsMIF expressionDisseminated coccidioidomycosisHealthy controlsLung epithelial cellsMIF levelsHigh-expression MIF allelesInhibitory factorEpithelial cellsFisher's exact testCATT5-8MIF polymorphismsSelf-identified African AmericansInflammatory cytokinesMIF allelesGranulomatous diseaseLow-expression allelePromoter polymorphismCoccidioidomycosis patientsPatientsExact test