2001
Regulation of the CTL Response by Macrophage Migration Inhibitory Factor
Abe R, Peng T, Sailors J, Bucala R, Metz C. Regulation of the CTL Response by Macrophage Migration Inhibitory Factor. The Journal Of Immunology 2001, 166: 747-753. PMID: 11145646, DOI: 10.4049/jimmunol.166.2.747.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAdoptive TransferAnimalsAntibodies, MonoclonalCD8-Positive T-LymphocytesCell MovementCells, CulturedCytotoxicity Tests, ImmunologicCytotoxicity, ImmunologicFemaleInjections, IntraperitonealLymphocytes, Tumor-InfiltratingMacrophage Migration-Inhibitory FactorsMiceMice, Inbred C57BLNeoplasm TransplantationT-Lymphocytes, CytotoxicThymomaTumor Cells, CulturedConceptsMacrophage migration inhibitory factorMigration inhibitory factorTumor-bearing miceCTL activityCTL responsesT lymphocytesAnti-tumor T lymphocytesInhibitory factorCultures of splenocytesApoptotic tumor cellsT cell survivalIL-2RPivotal cytokineT cellsHistological examinationImmune responseIFN-gammaSplenocyte culturesAg stimulationMouse modelTumor growthTumor tissueTumor cellsMiceElevated expression
2000
Protection from septic shock by neutralization of macrophage migration inhibitory factor
Calandra T, Echtenacher B, Roy D, Pugin J, Metz C, Hültner L, Heumann D, Männel D, Bucala R, Glauser M. Protection from septic shock by neutralization of macrophage migration inhibitory factor. Nature Medicine 2000, 6: 164-170. PMID: 10655104, DOI: 10.1038/72262.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorSeptic shockMigration inhibitory factorLethal peritonitisSevere sepsisMIF antibodyRecombinant macrophage migration inhibitory factorAnti-tumor necrosis factorInhibitory factorTNFα knockout micePathogenesis of sepsisPlasma of patientsNew therapeutic targetsBacterial peritonitisIll patientsInvestigational therapiesCecal ligationNecrosis factorNormal micePivotal cytokineSystemic circulationKnockout miceTherapeutic targetSepsisPeritonitis