Partial MHC class II constructs inhibit MIF/CD74 binding and downstream effects (P5221)
Benedek G, Meza-Romero R, Andrew S, Leng L, Burrows G, Bourdette D, Offner H, Bucala R, Vandenbark A. Partial MHC class II constructs inhibit MIF/CD74 binding and downstream effects (P5221). The Journal Of Immunology 2013, 190: 67.4-67.4. DOI: 10.4049/jimmunol.190.supp.67.4.Peer-Reviewed Original ResearchMacrophage migration inhibitory factorExperimental autoimmune encephalomyelitisPartial MHC class II constructsCD74 cell-surface expressionMultiple sclerosisCell surface expressionMIF/CD74 interactionMigration inhibitory factorAutoimmune encephalomyelitisAlpha 1 domainInflammatory activityProinflammatory cytokinesHistological signsMIF activityAnti-apoptotic activityImmune systemInhibitory factorEnhanced secretionMHC complexesAntigenic peptidesCD74MIF effectsRandom migrationSurface expressionPivotal regulator