1999
Macrophage migration inhibitory factor in rheumatoid arthritis: Evidence of proinflammatory function and regulation by glucocorticoids
Leech M, Metz C, Hall P, Hutchinson P, Gianis K, Smith M, Weedon H, Holdsworth S, Bucala R, Morand E. Macrophage migration inhibitory factor in rheumatoid arthritis: Evidence of proinflammatory function and regulation by glucocorticoids. Arthritis & Rheumatism 1999, 42: 1601-1608. PMID: 10446857, DOI: 10.1002/1529-0131(199908)42:8<1601::aid-anr6>3.0.co;2-b.Peer-Reviewed Original ResearchMeSH KeywordsAgedArthritis, RheumatoidCells, CulturedCytokinesGlucocorticoidsHumansImmunohistochemistryInterferon-gammaLymphocyte ActivationMacrophage Migration-Inhibitory FactorsMacrophagesMonocytesReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSynovial MembraneT-LymphocytesTumor Necrosis Factor-alphaConceptsMacrophage migration inhibitory factorFibroblast-like synoviocytesRA fibroblast-like synoviocytesEnzyme-linked immunosorbent assayRheumatoid arthritisMigration inhibitory factorTNFalpha releaseExpression of MIFIntracellular macrophage migration inhibitory factorInhibitory factorCultured RA fibroblast-like synoviocytesCytokine macrophage migration inhibitory factorCultured fibroblast-like synoviocytesTumor necrosis factor-alpha synthesisHuman RA synoviumRA synovial tissueNecrosis factor-alpha synthesisHuman autoimmune diseasesPotential therapeutic targetTranscription-polymerase chain reactionMessenger RNA expressionT cell activationMIF expressionRA patientsRA synovium
1996
Macrophage migration inhibitory factor production by Leydig cells: evidence for a role in the regulation of testicular function
Meinhardt A, Bacher M, McFarlane J, Metz C, Seitz J, Hedger M, de Kretser D, Bucala R. Macrophage migration inhibitory factor production by Leydig cells: evidence for a role in the regulation of testicular function. Endocrinology 1996, 137: 5090-5095. DOI: 10.1210/en.137.11.5090.Peer-Reviewed Original ResearchLeydig cellsMacrophage migration inhibitory factorSeminiferous tubulesRat testisHeads of elongated spermatidsRegulation of testicular functionAdult rat seminiferous tubulesTM3 Leydig cell lineTesticular functionLeydig cell steroidogenesis in vitroPeritubular myoid cellsLeydig cell lineAdult rat testisRat seminiferous tubulesPurified Leydig cellsMIF messenger RNAExpression of MIF messenger RNAMessenger RNALong-term hypophysectomized ratsIntracellular macrophage migration inhibitory factorMigration inhibitory factor productionProduct of activated T lymphocytesMurine macrophage migration inhibitory factorElongated spermatidsMacrophage migration inhibitory factor production