1999
A role for the endocrine and pro‐inflammatory mediator MIF in the control of insulin secretion during stress
Waeber G, Calandra T, Bonny C, Bucala R. A role for the endocrine and pro‐inflammatory mediator MIF in the control of insulin secretion during stress. Diabetes/Metabolism Research And Reviews 1999, 15: 47-54. PMID: 10398546, DOI: 10.1002/(sici)1520-7560(199901/02)15:1<47::aid-dmrr9>3.0.co;2-j.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorInsulin secretionMediator macrophage migration inhibitory factorSystemic inflammatory processSystemic inflammatory responseMigration inhibitory factorAnterior pituitary glandMIF levelsAdrenal axisInsulin resistanceGlucocorticoid effectsImmune cellsInflammatory processInflammatory responseInflammatory systemPeripheral tissuesGlucose homeostasisInsulin releaseHost immunityUtilization of glucosePituitary glandInhibitory factorAutocrine factorSystemic responseDisease states
1997
Insulin secretion is regulated by the glucose-dependent production of islet β cell macrophage migration inhibitory factor
Waeber G, Calandra T, Roduit R, Haefliger J, Bonny C, Thompson N, Thorens B, Temler E, Meinhardt A, Bacher M, Metz C, Nicod P, Bucala R. Insulin secretion is regulated by the glucose-dependent production of islet β cell macrophage migration inhibitory factor. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 4782-4787. PMID: 9114069, PMCID: PMC20802, DOI: 10.1073/pnas.94.9.4782.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMigration inhibitory factorInsulin releaseInsulin secretionBeta cellsRecombinant macrophage migration inhibitory factorInhibitory factorGlucose-induced insulin releasePancreatic islet beta cellsInsulin-secreting beta cellsINS-1 cell lineIslet beta cellsIsolated rat isletsInsulin secretion responseIslets of LangerhansConcentration-dependent mannerIslet cell productsImmune cellsT lymphocytesPituitary hormonesPerifusion studiesAutocrine fashionRat isletsSecretion responseGlucocorticoid stimulation