2005
Glucose-mediated DNA Damage and Mutations: In Vitro and In Vivo
Lee A, Cerami A, Bucala R. Glucose-mediated DNA Damage and Mutations: In Vitro and In Vivo. 2005, 249-253. DOI: 10.1533/9781845698393.4.249.Peer-Reviewed Original ResearchEukaryotic model systemsMammalian systemsTransgenic embryosTransgenic miceSignificant genetic alterationsDNA mutationsDNA damageBiological integrityGenetic alterationsMaternal environmentMutation frequencyModel systemNucleic acidsMutationsVitroVivoFunctional activityLacI.Nonenzymatic glycosylationEmbryosGlycosylationLacI mutation frequencyDNAComparative analysisMice
1995
A Role for DNA Mutations in Diabetes-Associated Teratogenesis in Transgenic Embryos
Lee A, Plump A, DeSimone C, Cerami A, Bucala R. A Role for DNA Mutations in Diabetes-Associated Teratogenesis in Transgenic Embryos. Diabetes 1995, 44: 20-24. PMID: 7813809, DOI: 10.2337/diab.44.1.20.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBlood GlucoseCongenital AbnormalitiesDiabetes Mellitus, ExperimentalDNAEmbryo, MammalianEmbryonic and Fetal DevelopmentFemaleHyperglycemiaLac OperonMaleMiceMice, TransgenicMolecular Sequence DataPolymerase Chain ReactionPregnancyPregnancy in DiabeticsConceptsDNA mutationsDiabetic environmentInsulin-dependent diabetic mothersMaternal diabetic environmentTransgenic mouse model systemCause of deathMouse model systemTransgenic embryosEmbryonic developmentTarget genesDiabetic mothersFetal malformationsGestational periodNormoglycemic conditionsCongenital malformationsHyperglycemic environmentDiabetic embryopathyFirst direct evidenceMutation frequencyModel systemGenotoxic effectsDiabetesMutant frequencyMalformationsTwofold increase
1994
Comparative analysis of DNA mutations in lacI transgenic mice with age
Lee A, Desimone C, Cerami A, Bucala R. Comparative analysis of DNA mutations in lacI transgenic mice with age. The FASEB Journal 1994, 8: 545-550. PMID: 8181674, DOI: 10.1096/fasebj.8.8.8181674.Peer-Reviewed Original Research