2022
Macrophage Migration Inhibitory Factor (MIF) Promotes Increased Proportions of the Highly Permissive Th17-like Cell Profile during HIV Infection
Trifone C, Baquero L, Czernikier A, Benencio P, Leng L, Laufer N, Quiroga MF, Bucala R, Ghiglione Y, Turk G. Macrophage Migration Inhibitory Factor (MIF) Promotes Increased Proportions of the Highly Permissive Th17-like Cell Profile during HIV Infection. Viruses 2022, 14: 2218. PMID: 36298774, PMCID: PMC9611675, DOI: 10.3390/v14102218.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMIF stimulationMIF treatmentIL-17AHIV infectionMIF/CD74 axisFounder HIV-1Functionality of CD4Higher IL-17AHigher MIF concentrationsMIF plasma levelsHIV-1 infectionMigration inhibitory factorPossible therapeutic targetMIF concentrationsIntracellular cytokinesR5-tropicCytokine productionIL-1βIL-6IL-8Plasma levelsHealthy donorsViral persistenceT lymphocytes
2000
The proinflammatory mediator macrophage migration inhibitory factor induces glucose catabolism in muscle
Benigni F, Atsumi T, Calandra T, Metz C, Echtenacher B, Peng T, Bucala R. The proinflammatory mediator macrophage migration inhibitory factor induces glucose catabolism in muscle. Journal Of Clinical Investigation 2000, 106: 1291-1300. PMID: 11086030, PMCID: PMC381433, DOI: 10.1172/jci9900.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCell MovementFructosediphosphatesGlucoseGlycolysisHumansLactic AcidLiverMacrophage Migration-Inhibitory FactorsMacrophagesMiceMusclesPhosphofructokinase-2Phosphoric Monoester HydrolasesPhosphotransferases (Alcohol Group Acceptor)RatsTumor Cells, CulturedTumor Necrosis Factor-alphaConceptsMacrophage migration inhibitory factorMigration inhibitory factorTNF-alphaInhibitory factorTNF-alpha knockout miceMediator macrophage migration inhibitory factorAddition of MIFSystemic inflammatory responseSevere metabolic derangementProinflammatory cytokine productionSerum glucose levelsImmune cell activationAnterior pituitary glandPositive allosteric regulatorMetabolic derangementsAutocrine stimuliCytokine productionGlucose disposalImmune cellsSevere infectionsCatabolic effectsInflammatory responseGlucose levelsInsulin releaseCatabolic response
1998
Macrophage migration inhibitory factor is a critical mediator of the activation of immune cells by exotoxins of Gram-positive bacteria
Calandra T, Spiegel L, Metz C, Bucala R. Macrophage migration inhibitory factor is a critical mediator of the activation of immune cells by exotoxins of Gram-positive bacteria. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 11383-11388. PMID: 9736745, PMCID: PMC21651, DOI: 10.1073/pnas.95.19.11383.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodiesBacterial ToxinsCell DivisionCells, CulturedDisease Models, AnimalEnterotoxinsExotoxinsGram-Positive BacteriaInflammationInterferon-gammaInterleukin-2Lymphocyte ActivationMacrophage Migration-Inhibitory FactorsMacrophages, PeritonealMicePituitary GlandShock, SepticSpleenStaphylococcusStreptococcusSuperantigensConceptsMacrophage migration inhibitory factorMigration inhibitory factorMIF secretionInhibitory factorStaphylococcal toxic shock syndrome toxin 1Toxic shock syndrome toxin-1Anti-MIF antibodiesSplenocyte cytokine productionTSST-1 injectionInterferon-gamma secretionLethal mouse modelStreptococcal pyrogenic exotoxinT cell cytokinesInnate host responseLethal toxic shockProliferation of splenocytesT-cell productsInnate immune responseSyndrome toxin-1Dose-response studyMouse peritoneal macrophagesSpleen enlargementMIF antibodyC57BL/6 miceCytokine productionNeuroimmunomodulation by Macrophage Migration Inhibitory Factor (MIF)
BUCALA R. Neuroimmunomodulation by Macrophage Migration Inhibitory Factor (MIF). Annals Of The New York Academy Of Sciences 1998, 840: 74-82. PMID: 9629239, DOI: 10.1111/j.1749-6632.1998.tb09551.x.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMigration inhibitory factorImmune responseRole of MIFInhibitory factorT cell cytokine productionAnti-inflammatory propertiesAnterior pituitary cellsT-lymphocyte factorSteroid therapyLymph nodesCytokine productionImmunosuppressive effectsInflammatory conditionsGlucocorticoid actionT cellsFirst cytokineInflammatory sitesTherapeutic strategiesProinflammatory stimuliPituitary cellsImmune systemLymphocyte factorsGlucocorticoidsInhibitory effectMIF Expression in the Rat Brain: Implications for Neuronal Function
Bacher M, Meinhardt A, Lan H, Dhabhar F, Mu W, Metz C, Chesney J, Gemsa D, Donnelly T, Atkins R, Bucala R. MIF Expression in the Rat Brain: Implications for Neuronal Function. Molecular Medicine 1998, 4: 217-230. PMID: 9606175, PMCID: PMC2230367, DOI: 10.1007/bf03401919.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMIF mRNA expressionMIF expressionMIF mRNAMIF immunoreactivityMIF proteinGlucocorticoid actionRecombinant macrophage migration inhibitory factorNeuroendocrine systemMRNA expressionSystemic inflammatory responseInflammatory stress responseMigration inhibitory factorCerebrospinal fluid contentAnterior pituitary glandMonocytes/macrophagesTNF-α proteinHippocampal CA3 fieldTotal brain RNAProinflammatory factorsMIF antibodySitu hybridizationIntracisternal injectionBaseline expression patternCytokine production
1996
MIF rediscovered: cytokine, pituitary hormone, and glucocorticoid‐induced regulator of the immune response
Bucala R. MIF rediscovered: cytokine, pituitary hormone, and glucocorticoid‐induced regulator of the immune response. The FASEB Journal 1996, 10: 1607-1613. PMID: 9002552, DOI: 10.1096/fasebj.10.14.9002552.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorImmune responseSecretion of MIFMigration inhibitory factorAnterior pituitary cellsImmune cell activationT-lymphocyte productsProfound inhibitory effectFirst cytokine activitiesCounterregulatory hormonesLymph nodesCytokine productionImmunosuppressive effectsGlucocorticoid actionLymphocyte productsT cellsPituitary hormonesInflammatory sitesCytokine activityPituitary cellsSteroid concentrationsCell activationImmune systemInhibitory factorInhibitory effectMIF re-discovered: Pituitary hormone and glucocorticoid-induced regulator of cytokine production
Bucala R. MIF re-discovered: Pituitary hormone and glucocorticoid-induced regulator of cytokine production. Cytokine & Growth Factor Reviews 1996, 7: 19-24. PMID: 8864351, DOI: 10.1016/1359-6101(96)00008-1.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorAssociation of MIFT cell-derived factorsCounter-regulatory hormonesPrimary immune responseMigration inhibitory factorCell-derived factorSource of infectionAnterior pituitary cell lineFirst cytokine activitiesLymph nodesCytokine productionGlucocorticoid actionPituitary cell lineImmune responsePituitary hormonesInflammatory sitesCytokine activityHost responseImmune systemInhibitory factorInhibitory effectTissue invasionProtein mediatorsRandom migration
1995
Localization of Macrophage Migration Inhibitory Factor (MIF) to Secretory Granules within the Corticotrophic and Thyrotrophic Cells of the Pituitary Gland
Nishino T, Bernhagen J, Shiiki H, Calandra T, Dohi K, Bucala R. Localization of Macrophage Migration Inhibitory Factor (MIF) to Secretory Granules within the Corticotrophic and Thyrotrophic Cells of the Pituitary Gland. Molecular Medicine 1995, 1: 781-788. PMID: 8612200, PMCID: PMC2230018, DOI: 10.1007/bf03401892.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorRelease of MIFCorticotropin-releasing hormoneMigration inhibitory factorAnterior pituitary glandPituitary glandThyrotrophic cellsBackgroundMacrophage migration inhibitory factorInhibitory factorCorticotrophic cellsAnterior pituitary hormonesActivated T lymphocytesHormone-specific antibodiesSubsets of granulesGlucocorticoid suppressionSeptic shockLPS injectionCytokine productionEndotoxin administrationACTH releaseT lymphocytesConclusionsThese dataPituitary hormonesPituitary contentHost responseMIF as a glucocorticoid-induced modulator of cytokine production
Calandra T, Bernhagen J, Metz C, Spiegel L, Bacher M, Donnelly T, Cerami A, Bucala R. MIF as a glucocorticoid-induced modulator of cytokine production. Nature 1995, 377: 68-71. PMID: 7659164, DOI: 10.1038/377068a0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCell LineCytokinesDexamethasoneEnzyme-Linked Immunosorbent AssayFemaleGlucocorticoidsHumansHydrocortisoneImmunityInflammationLipopolysaccharidesMacrophage ActivationMacrophage Migration-Inhibitory FactorsMacrophagesMiceMice, Inbred BALB CRatsRats, Sprague-DawleyRecombinant ProteinsShock, SepticT-LymphocytesConceptsMacrophage migration inhibitory factorCounter-regulatory systemsMigration inhibitory factorProtein macrophage migration inhibitory factorGlucocorticoid protectionLethal endotoxaemiaMIF productionCytokine productionCytokine secretionMacrophage cytokinesEndogenous mediatorsImmunosuppressive propertiesImmune responseGlucocorticoid hormonesInhibitory factorHormonal systemsCritical mediatorUnexpected findingMediatorsVital functionsEndotoxaemiaCytokinesGlucocorticoidsMonocytesPituitary