2021
Intravesical CD74 and CXCR4, macrophage migration inhibitory factor (MIF) receptors, mediate bladder pain
Ye S, Ma F, Mahmood DFD, Meyer-Siegler KL, Menard RE, Hunt DE, Leng L, Bucala R, Vera PL. Intravesical CD74 and CXCR4, macrophage migration inhibitory factor (MIF) receptors, mediate bladder pain. PLOS ONE 2021, 16: e0255975. PMID: 34424927, PMCID: PMC8382170, DOI: 10.1371/journal.pone.0255975.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorHigh mobility group box 1Bladder painMIF receptorHMGB1 releaseBladder hyperalgesiaMobility group box 1MIF receptor CD74Migration inhibitory factorGroup box 1Primary urothelial cellsInhibitory factor receptorWarrants further investigationCD74 receptorReceptor CD74Micturition parametersReceptor antagonistReceptor 4Box 1PainInhibitory factorHyperalgesiaCD74Urothelial cellsNovel targetCD74 is a regulator of hematopoietic stem cell maintenance
Becker-Herman S, Rozenberg M, Hillel-Karniel C, Gil-Yarom N, Kramer M, Barak A, Sever L, David K, Radomir L, Lewinsky H, Levi M, Friedlander G, Bucala R, Peled A, Shachar I. CD74 is a regulator of hematopoietic stem cell maintenance. PLOS Biology 2021, 19: e3001121. PMID: 33661886, PMCID: PMC7963458, DOI: 10.1371/journal.pbio.3001121.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntigens, Differentiation, B-LymphocyteBone Marrow CellsBone Marrow TransplantationCell LineageFemaleHealthy VolunteersHematopoietic Stem CellsHistocompatibility Antigens Class IIHumansIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMaleMiceMice, Inbred C57BLSignal TransductionConceptsMacrophage migration inhibitory factorHematopoietic stem cellsBone marrowCytokine macrophage migration inhibitory factorMigration inhibitory factorNumber of HSPCsTransplant protocolsCD18 expressionClinical transplantationInduced SurvivalCD74Inhibitory factorBM nicheCell surface receptorsSelf-renewal propertiesClinical insightsProgenitor cellsBlood cell lineagesSurface receptorsStem cellsHematopoietic stemCell lineagesCellsUndifferentiated cellsHematopoietic stem cell maintenance
2013
Partial MHC class II constructs inhibit MIF/CD74 binding and downstream effects (P5221)
Benedek G, Meza-Romero R, Andrew S, Leng L, Burrows G, Bourdette D, Offner H, Bucala R, Vandenbark A. Partial MHC class II constructs inhibit MIF/CD74 binding and downstream effects (P5221). The Journal Of Immunology 2013, 190: 67.4-67.4. DOI: 10.4049/jimmunol.190.supp.67.4.Peer-Reviewed Original ResearchMacrophage migration inhibitory factorExperimental autoimmune encephalomyelitisPartial MHC class II constructsCD74 cell-surface expressionMultiple sclerosisCell surface expressionMIF/CD74 interactionMigration inhibitory factorAutoimmune encephalomyelitisAlpha 1 domainInflammatory activityProinflammatory cytokinesHistological signsMIF activityAnti-apoptotic activityImmune systemInhibitory factorEnhanced secretionMHC complexesAntigenic peptidesCD74MIF effectsRandom migrationSurface expressionPivotal regulator
2011
1038 MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) ACTS AS AN ANTI-FIBROTIC CYTOKINE IN EXPERIMENTAL LIVER FIBROSIS VIA CD74 AND AMPK
Heinrichs P, Jung M, Offermanns C, Berres M, Nellen A, Schmitz P, Leng L, Bucala R, Trautwein C, Weber C, Bernhagen J, Wasmuth H. 1038 MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) ACTS AS AN ANTI-FIBROTIC CYTOKINE IN EXPERIMENTAL LIVER FIBROSIS VIA CD74 AND AMPK. Journal Of Hepatology 2011, 54: s413. DOI: 10.1016/s0168-8278(11)61040-4.Peer-Reviewed Original Research