Bladder Oxidative Stress and HMGB1 Release Contribute to PAR4-Mediated Bladder Pain in Mice
Ye S, Ma F, Mahmood DFD, Meyer-Siegler KL, Leng L, Bucala R, Vera PL. Bladder Oxidative Stress and HMGB1 Release Contribute to PAR4-Mediated Bladder Pain in Mice. Frontiers In Systems Neuroscience 2022, 16: 882493. PMID: 35645739, PMCID: PMC9135998, DOI: 10.3389/fnsys.2022.882493.Peer-Reviewed Original ResearchHigh mobility group box 1Macrophage migration inhibitory factorBladder painIntravesical fluidOxidative stressLevels of HMGB1Mobility group box 1Bladder oxidative stressFemale C57BL/6 miceMigration inhibitory factorGroup box 1Possible therapeutic strategiesN-acetylcysteine amideBladder edemaMIF antagonismMIF deficiencyHMGB1 concentrationsMicturition frequencyMicturition volumeMIF releaseHMGB1 levelsC57BL/6 miceMicturition parametersHistological signsHistological evidenceMP07-05 BLADDER OXIDATIVE STRESS AND ERK SIGNALING CONTRIBUTE TO BLADDER PAIN MEDIATED BY MACROPHAGE MIGRATION INHIBITORY FACTOR AND HIGH MOBILITY GROUP BOX 1
Ye S, Ma F, Mahmood D, Meyer-Siegler K, Leng L, Bucala R, Vera P. MP07-05 BLADDER OXIDATIVE STRESS AND ERK SIGNALING CONTRIBUTE TO BLADDER PAIN MEDIATED BY MACROPHAGE MIGRATION INHIBITORY FACTOR AND HIGH MOBILITY GROUP BOX 1. Journal Of Urology 2022, 207: e116. DOI: 10.1097/ju.0000000000002529.05.Peer-Reviewed Original Research