2000
The proinflammatory mediator macrophage migration inhibitory factor induces glucose catabolism in muscle
Benigni F, Atsumi T, Calandra T, Metz C, Echtenacher B, Peng T, Bucala R. The proinflammatory mediator macrophage migration inhibitory factor induces glucose catabolism in muscle. Journal Of Clinical Investigation 2000, 106: 1291-1300. PMID: 11086030, PMCID: PMC381433, DOI: 10.1172/jci9900.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCell MovementFructosediphosphatesGlucoseGlycolysisHumansLactic AcidLiverMacrophage Migration-Inhibitory FactorsMacrophagesMiceMusclesPhosphofructokinase-2Phosphoric Monoester HydrolasesPhosphotransferases (Alcohol Group Acceptor)RatsTumor Cells, CulturedTumor Necrosis Factor-alphaConceptsMacrophage migration inhibitory factorMigration inhibitory factorTNF-alphaInhibitory factorTNF-alpha knockout miceMediator macrophage migration inhibitory factorAddition of MIFSystemic inflammatory responseSevere metabolic derangementProinflammatory cytokine productionSerum glucose levelsImmune cell activationAnterior pituitary glandPositive allosteric regulatorMetabolic derangementsAutocrine stimuliCytokine productionGlucose disposalImmune cellsSevere infectionsCatabolic effectsInflammatory responseGlucose levelsInsulin releaseCatabolic response
1999
A role for the endocrine and pro‐inflammatory mediator MIF in the control of insulin secretion during stress
Waeber G, Calandra T, Bonny C, Bucala R. A role for the endocrine and pro‐inflammatory mediator MIF in the control of insulin secretion during stress. Diabetes/Metabolism Research And Reviews 1999, 15: 47-54. PMID: 10398546, DOI: 10.1002/(sici)1520-7560(199901/02)15:1<47::aid-dmrr9>3.0.co;2-j.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorInsulin secretionMediator macrophage migration inhibitory factorSystemic inflammatory processSystemic inflammatory responseMigration inhibitory factorAnterior pituitary glandMIF levelsAdrenal axisInsulin resistanceGlucocorticoid effectsImmune cellsInflammatory processInflammatory responseInflammatory systemPeripheral tissuesGlucose homeostasisInsulin releaseHost immunityUtilization of glucosePituitary glandInhibitory factorAutocrine factorSystemic responseDisease states
1998
MIF Expression in the Rat Brain: Implications for Neuronal Function
Bacher M, Meinhardt A, Lan H, Dhabhar F, Mu W, Metz C, Chesney J, Gemsa D, Donnelly T, Atkins R, Bucala R. MIF Expression in the Rat Brain: Implications for Neuronal Function. Molecular Medicine 1998, 4: 217-230. PMID: 9606175, PMCID: PMC2230367, DOI: 10.1007/bf03401919.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMIF mRNA expressionMIF expressionMIF mRNAMIF immunoreactivityMIF proteinGlucocorticoid actionRecombinant macrophage migration inhibitory factorNeuroendocrine systemMRNA expressionSystemic inflammatory responseInflammatory stress responseMigration inhibitory factorCerebrospinal fluid contentAnterior pituitary glandMonocytes/macrophagesTNF-α proteinHippocampal CA3 fieldTotal brain RNAProinflammatory factorsMIF antibodySitu hybridizationIntracisternal injectionBaseline expression patternCytokine production
1997
Macrophage migration inhibitory factor: a regulator of glucocorticoid activity with a critical role in inflammatory disease
Donnelly S, Bucala R. Macrophage migration inhibitory factor: a regulator of glucocorticoid activity with a critical role in inflammatory disease. Trends In Molecular Medicine 1997, 3: 502-507. PMID: 9430786, DOI: 10.1016/s1357-4310(97)01133-7.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorAcute respiratory distress syndromeRelease of MIFFunction of MIFEfficacy of glucocorticoidsRespiratory distress syndromeAnti-inflammatory effectsMigration inhibitory factorEffects of glucocorticoidsAnterior pituitary glandARDS pathogenesisDistress syndromeGlucocorticoid activityInflammatory diseasesT cellsFirst cytokineInflammatory sitesPituitary glandInhibitory factorGlucocorticoidsCritical rolePhysiological responsesCytokinesPathogenesisSyndromeMacrophage Migration Inhibitory Factor (MIF): A Glucocorticoid Counter-Regulator within the Immune System
Calandra T, Bucala R. Macrophage Migration Inhibitory Factor (MIF): A Glucocorticoid Counter-Regulator within the Immune System. Critical Reviews In Immunology 1997, 17: 77-88. PMID: 9034724, DOI: 10.1615/critrevimmunol.v17.i1.30.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCattleChickensGene Expression RegulationGlucocorticoidsHumansInterferon-gammaInterleukinsLipopolysaccharidesMacrophage Migration-Inhibitory FactorsMacrophagesMiceMolecular Sequence DataMolecular StructurePituitary GlandRatsSequence Homology, Amino AcidShock, SepticT-LymphocytesTumor Necrosis Factor-alphaConceptsMacrophage migration inhibitory factorMigration inhibitory factorImmune responseImmune systemT lymphocyte-derived factorInhibitory factorInhibitory effectLymphocyte-derived factorRecombinant MIF proteinIFN-gamma productionIL-1 betaIL-8 productionT cell proliferationAnterior pituitary glandEnigmatic cytokineLethal endotoxemiaIL-6MIF proteinIL-2TNF-alphaCounter regulatorT lymphocytesProtective effectGlucocorticoid inhibitionPituitary glandRole of Macrophage Migration Inhibitory Factor in the Regulation of the Immune Response
Metz C, Bucala R. Role of Macrophage Migration Inhibitory Factor in the Regulation of the Immune Response. Advances In Immunology 1997, 66: 197-223. PMID: 9328642, DOI: 10.1016/s0065-2776(08)60598-2.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMigration inhibitory factorT cellsImmune responseInhibitory factorAnti-inflammatory effectsInflammatory disease statesAnterior pituitary glandSeptic shockMIF actionMIF proteinInflammatory responseGlucocorticoid actionImmune systemPituitary glandCorticotrophic cellsGlucocorticoidsInhibitory effectDisease statesBaseline statePotential roleMacrophagesCellsResponseArthritis
1995
Localization of Macrophage Migration Inhibitory Factor (MIF) to Secretory Granules within the Corticotrophic and Thyrotrophic Cells of the Pituitary Gland
Nishino T, Bernhagen J, Shiiki H, Calandra T, Dohi K, Bucala R. Localization of Macrophage Migration Inhibitory Factor (MIF) to Secretory Granules within the Corticotrophic and Thyrotrophic Cells of the Pituitary Gland. Molecular Medicine 1995, 1: 781-788. PMID: 8612200, PMCID: PMC2230018, DOI: 10.1007/bf03401892.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorRelease of MIFCorticotropin-releasing hormoneMigration inhibitory factorAnterior pituitary glandPituitary glandThyrotrophic cellsBackgroundMacrophage migration inhibitory factorInhibitory factorCorticotrophic cellsAnterior pituitary hormonesActivated T lymphocytesHormone-specific antibodiesSubsets of granulesGlucocorticoid suppressionSeptic shockLPS injectionCytokine productionEndotoxin administrationACTH releaseT lymphocytesConclusionsThese dataPituitary hormonesPituitary contentHost response
1994
Macrophage migration inhibitory factor is a neuroendocrine mediator of endotoxaemia
Bernhagen J, Calandra T, Cerami A, Bucala R. Macrophage migration inhibitory factor is a neuroendocrine mediator of endotoxaemia. Trends In Microbiology 1994, 2: 198-201. PMID: 8087451, DOI: 10.1016/0966-842x(94)90111-h.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMigration inhibitory factorInhibitory factorCytokine macrophage migration inhibitory factorDelayed-type hypersensitivity reactionSystemic inflammatory responseIdentification of MIFT-cell productsCentral nervous systemAnterior pituitary glandHypersensitivity reactionsNeuroendocrine mediatorsInflammatory responseNervous systemPituitary glandCell productsEndotoxaemiaMajor protein constituentPituitaryHormoneProtein constituents