1985
Determination of 16 alpha‐hydroxyestrone by radioimmunoassay in systemic lupus erythematosus
Lahita R, Bucala R, Bradlow H, Fishman J. Determination of 16 alpha‐hydroxyestrone by radioimmunoassay in systemic lupus erythematosus. Arthritis & Rheumatism 1985, 28: 1122-1127. PMID: 4052123, DOI: 10.1002/art.1780281007.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusActive diseaseLupus erythematosusInactive systemic lupus erythematosusVariety of seraInactive diseaseSLE patientsAntibody levelsComplement levelsRheumatic diseasesLaboratory criteriaAlpha-hydroxyestroneHormone levelsHealthy volunteersNormal controlsPatientsEstrogenic metabolitesNormal levelsDiseaseErythematosusSignificant increaseRadioimmunoassayPoor correlationMetabolitesHigh levelsIncreased Levels of 16α-Hydroxyestrone-Modified Proteins in Pregnancy and in Systemic Lupus Erythematosus*
BUCALA R, LAHITA R, FISHMAN J, CERAMI A. Increased Levels of 16α-Hydroxyestrone-Modified Proteins in Pregnancy and in Systemic Lupus Erythematosus*. The Journal Of Clinical Endocrinology & Metabolism 1985, 60: 841-847. PMID: 3920233, DOI: 10.1210/jcem-60-5-841.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusLupus erythematosusPregnant womenHigher mean levelsNormal womenAlpha-hydroxyestroneFemale hormonesNormal subjectsErythematosusNormal levelsElevated levelsMean levelsWomenLatter groupRed cellsLymphocyte proteinSimilar elevationsPregnancyOHEBasement membrane proteinsUseful indicatorLevelsPatientsModification of proteinsLymphocytesRole of Sex Steroids in Systemic Lupus Erythematosus (SLE)
LAHITA R, BUCALA R, BRADLOW H, FISHMAN J. Role of Sex Steroids in Systemic Lupus Erythematosus (SLE). Protides Of The Biological Fluids 1985, 33: 301-304. DOI: 10.1016/b978-0-08-033215-4.50074-1.Peer-Reviewed Original ResearchSystemic lupus erythematosusPathogenesis of SLESex steroidsHydroxylation of estroneLower plasma androgenActive diseaseLupus erythematosusEstrogen metabolismAlpha-hydroxyestroneOxidation of testosteronePlasma androgensPotent estrogenDiseasePathogenesisSteroidsFemalesMalesMetabolismLow levelsErythematosusPatientsAndrogensEstrogenTestosteroneCell membrane
1983
Characterization of antisera to the addition product formed by the nonenzymatic reaction of 16α-hydroxyestrone with albumin
Bucala R, Cerami A. Characterization of antisera to the addition product formed by the nonenzymatic reaction of 16α-hydroxyestrone with albumin. Molecular Immunology 1983, 20: 1289-1292. PMID: 6656775, DOI: 10.1016/0161-5890(83)90159-1.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusLupus erythematosusAutoimmune diseasesAlpha-hydroxyestroneHigh-titre antiseraLack of specificityCross-reactivity analysisPhenolic A-ringElevated levelsCharacterization of antiseraLow molar substitutionOHEAntiserumImmunochemical analysisHigh specificityAlbuminHigh affinity