1998
Local Regulation of Macrophage Subsets in the Adult Rat Testis: Examination of the Roles of the Seminiferous Tubules, Testosterone, and Macrophage-Migration Inhibitory Factor1
Meinhardt A, Bacher M, Metz C, Bucala R, Wreford N, Lan H, Atkins R, Hedger M. Local Regulation of Macrophage Subsets in the Adult Rat Testis: Examination of the Roles of the Seminiferous Tubules, Testosterone, and Macrophage-Migration Inhibitory Factor1. Biology Of Reproduction 1998, 59: 371-378. PMID: 9687310, DOI: 10.1095/biolreprod59.2.371.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorSeminiferous tubule functionLeydig cell functionAdult rat testisMacrophage subsetsMacrophage numbersT implantsTubule functionAbdominal testesRat testisLeydig cellsResident macrophagesCytokine macrophage migration inhibitory factorMonocyte/macrophage subsetsCell functionMacrophage surface antigensResident macrophage numbersMacrophage migration inhibitoryMonoclonal antibody ED2MIF levelsLack of expressionSurface antigenInhibitory factorTestosterone implantsScrotal testes
1996
Macrophage migration inhibitory factor production by Leydig cells: evidence for a role in the regulation of testicular function
Meinhardt A, Bacher M, McFarlane J, Metz C, Seitz J, Hedger M, de Kretser D, Bucala R. Macrophage migration inhibitory factor production by Leydig cells: evidence for a role in the regulation of testicular function. Endocrinology 1996, 137: 5090-5095. DOI: 10.1210/en.137.11.5090.Peer-Reviewed Original ResearchLeydig cellsMacrophage migration inhibitory factorSeminiferous tubulesRat testisHeads of elongated spermatidsRegulation of testicular functionAdult rat seminiferous tubulesTM3 Leydig cell lineTesticular functionLeydig cell steroidogenesis in vitroPeritubular myoid cellsLeydig cell lineAdult rat testisRat seminiferous tubulesPurified Leydig cellsMIF messenger RNAExpression of MIF messenger RNAMessenger RNALong-term hypophysectomized ratsIntracellular macrophage migration inhibitory factorMigration inhibitory factor productionProduct of activated T lymphocytesMurine macrophage migration inhibitory factorElongated spermatidsMacrophage migration inhibitory factor production