2023
Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis
Moledina D, Obeid W, Smith R, Rosales I, Sise M, Moeckel G, Kashgarian M, Kuperman M, Campbell K, Lefferts S, Meliambro K, Bitzer M, Perazella M, Luciano R, Pober J, Cantley L, Colvin R, Wilson F, Parikh C. Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis. Journal Of Clinical Investigation 2023, 133: e168950. PMID: 37395276, PMCID: PMC10313360, DOI: 10.1172/jci168950.Peer-Reviewed Original ResearchConceptsUrinary CXCL9External validation cohortValidation cohortControl groupAIN diagnosisDiscovery cohortKidney tissueDiagnostic biomarkersAcute interstitial nephritisCXCL9 mRNA expressionAcute kidney injuryBiopsy-confirmed diagnosisAvailable clinical testsNational InstituteKidney injuryTubulointerstitial nephritisInterstitial nephritisKidney biopsyHistological confirmationHistological diagnosisTreatment optionsLymphocyte chemotaxisCXCL9MRNA expression differencesPatients
2022
Infiltrative Disease of the Tubulointerstitium
Aklilu A, Luciano R. Infiltrative Disease of the Tubulointerstitium. 2022, 231-241. DOI: 10.1007/978-3-030-93438-5_18.Peer-Reviewed Original ResearchInfiltrative diseasePlasma cell disordersRenal cell carcinomaRenal tubular cellsWhite blood cellsCancer-targeted therapyKidney injuryPrimary malignancySecondary inflammationTubular damageTubulointerstitial nephritisBronchogenic carcinomaInfiltrative lesionsLymphoproliferative disordersCell carcinomaMetastatic spreadBreast cancerPrimary involvementNormal kidneySolid cancersCell disordersTubular cellsTubular lumenBlood cellsDisease
2021
Lysozyme nephropathy: A rare and reversible cause of acute kidney injury in chronic myelomonocytic leukemia
Donati A, Luciano R, Shirali A. Lysozyme nephropathy: A rare and reversible cause of acute kidney injury in chronic myelomonocytic leukemia. Journal Of Onco-Nephrology 2021, 5: 120-121. DOI: 10.1177/23993693211026926.Peer-Reviewed Case Reports and Technical Notes
2020
37 Kidney disease in leukemia
LUCIANO R. 37 Kidney disease in leukemia. 2020, 337-346.e1. DOI: 10.1016/b978-0-323-54945-5.00046-1.Peer-Reviewed Original ResearchAcute kidney injuryKidney injuryDevelopment of AKIPrerenal acute kidney injuryAcute tubular necrosisSolid organ malignanciesAcid-base abnormalitiesBone marrow cellsUnderlying malignancyRenovascular diseaseOrgan malignanciesTubular necrosisParenchymal infiltrationSecondary complicationsKidney diseaseCommon cancerHematologic malignanciesDisease manifestationsLeukemiaMarrow cellsMalignancyInjuryDiseaseKidneyBroad spectrum38 Kidney disease in lymphoma
LUCIANO R. 38 Kidney disease in lymphoma. 2020, 347-354.e1. DOI: 10.1016/b978-0-323-54945-5.00047-3.Peer-Reviewed Original ResearchKidney injuryPrerenal acute kidney injuryAcute kidney injuryAcute tubular necrosisNon-Hodgkin lymphomaTreatment of lymphomaAcid-base abnormalitiesComorbid illnessesRenovascular diseaseTubular necrosisLymph nodesParenchymal infiltrationKidney manifestationsProgressive injuryKidney diseaseHematologic malignanciesLymph tissueLymphoid cellsSide effectsLymphomaAbnormal proliferationInjuryPatientsDiseaseMalignancy
2019
Medication-Associated Glomerular Disease
Tucker B, Luciano R. Medication-Associated Glomerular Disease. 2019, 735-772. DOI: 10.1007/978-3-319-49379-4_46.Peer-Reviewed Original ResearchGlomerular diseaseTubule-interstitial diseaseMinimal change diseaseFocal segmental glomerulosclerosisKidney injuryThrombotic microangiopathyAcute hemodynamicsCrystalline nephropathyChange diseaseHistologic patternSegmental glomerulosclerosisAdditional interventionsMedicationsDisease severitySpecific drugsDiseaseInjuryDrugsVasculitisHematuriaMicroangiopathyProteinuriaDiscontinuationGlomerulonephritisNephropathy
2018
Drug-Induced Acute Kidney Injury
Luciano R, Perazella M. Drug-Induced Acute Kidney Injury. 2018, 145-163. DOI: 10.1007/978-1-4939-8628-6_9.Peer-Reviewed Original ResearchDrug-induced acute kidney injuryAcute kidney injuryKidney injuryAcute tubular injury/necrosisAcute interstitial nephritisFocal segmental glomerulosclerosisDrugs/substancesOsmotic nephropathyRisk patientsInterstitial nephritisKidney functionPrescribed medicationsSegmental glomerulosclerosisEarly identificationRenal compartmentsInjuryHarmful drugsTherapeutic agentsAdverse effectsCommon formDrugsMedicationsKidneyCommon problemDiagnostic agents33 Acute Interstitial Nephritis
Brewster U, Luciano R. 33 Acute Interstitial Nephritis. 2018, 320-325. DOI: 10.1016/b978-0-323-47794-9.00033-0.Peer-Reviewed Original ResearchAcute interstitial nephritisInterstitial nephritisCellular interstitial infiltratesForm of AKITriad of feverSetting of infectionUrine of patientsOccasional plasma cellsRenal tubular cellsKidney injuryMedication exposureSterile pyuriaCulprit medicationKidney biopsyMild proteinuriaInterstitial infiltratesSystemic diseaseAutoimmune diseasesDefinitive diagnosisCommon causePlasma cellsImmune responseUrine sedimentTubular cellsRapid treatment
2017
Medication-Associated Glomerular Disease
Tucker B, Luciano R. Medication-Associated Glomerular Disease. 2017, 1-36. DOI: 10.1007/978-3-319-27334-1_46-1.Peer-Reviewed Original ResearchGlomerular diseaseTubule-interstitial diseaseMinimal change diseaseFocal segmental glomerulosclerosisKidney injuryThrombotic microangiopathyAcute hemodynamicsCrystalline nephropathyChange diseaseHistologic patternSegmental glomerulosclerosisAdditional interventionsMedicationsDisease severitySpecific drugsDiseaseInjuryDrugsVasculitisHematuriaMicroangiopathyProteinuriaDiscontinuationGlomerulonephritisNephropathy
2014
Nephrotoxic effects of designer drugs: synthetic is not better!
Luciano RL, Perazella MA. Nephrotoxic effects of designer drugs: synthetic is not better! Nature Reviews Nephrology 2014, 10: 314-324. PMID: 24662435, DOI: 10.1038/nrneph.2014.44.BooksKidney Involvement in Leukemia and Lymphoma
Luciano RL, Brewster UC. Kidney Involvement in Leukemia and Lymphoma. Advances In Kidney Disease And Health 2014, 21: 27-35. PMID: 24359984, DOI: 10.1053/j.ackd.2013.07.004.BooksConceptsAcute kidney injuryKidney involvementOvert kidney failureAcute tubular necrosisMultiorgan system involvementLife-threatening consequencesForms of leukemiaAcid-base disordersObstructive etiologyKidney injuryElectrolyte disturbancesTubular necrosisCommon etiologyNephrotic syndromeKidney failureSystem involvementHematologic malignanciesSide effectsDirect effectMalignancyAge groupsLymphomaLeukemiaComplicationsEtiology
2013
Acute Kidney Injury From Cherry Concentrate in a Patient With CKD
Luciano RL. Acute Kidney Injury From Cherry Concentrate in a Patient With CKD. American Journal Of Kidney Diseases 2013, 63: 503-505. PMID: 24290246, DOI: 10.1053/j.ajkd.2013.09.021.Peer-Reviewed Case Reports and Technical NotesConceptsAcute kidney injuryKidney injuryKidney diseaseNonsteroidal anti-inflammatory medicationsAnti-inflammatory medicationsChronic kidney diseaseCherry concentrateMethod of injuryMultiple organ systemsMechanism of actionSignificant morbidityHarmful side effectsCyclooxygenase inhibitionNumerous health benefitsMedical foodsSide effectsOrgan systemsHyperkalemiaInjuryPatientsDaily consumptionAdverse effectsHealth benefitsCherry extractDiseaseWarfarin-related nephropathy in a patient with mild IgA nephropathy on dabigatran and aspirin
Moeckel GW, Luciano RL, Brewster UC. Warfarin-related nephropathy in a patient with mild IgA nephropathy on dabigatran and aspirin. Clinical Kidney Journal 2013, 6: 507-509. PMID: 26120444, PMCID: PMC4438392, DOI: 10.1093/ckj/sft076.Peer-Reviewed Case Reports and Technical NotesAcute kidney injuryTubular injuryIgA nephropathyMild IgA nephropathyAcute tubular injuryLong-term anticoagulationDirect thrombin inhibitorKidney injurySevere hematuriaRenal biopsyGlomerular pathologyDabigatranPatientsThrombin inhibitorsNephropathyInjuryWarfarinAnticoagulationHematuriaAspirinBiopsyPathologyBabesiosis-Induced Acute Kidney Injury With Prominent Urinary Macrophages
Luciano RL, Moeckel G, Palmer M, Perazella MA. Babesiosis-Induced Acute Kidney Injury With Prominent Urinary Macrophages. American Journal Of Kidney Diseases 2013, 62: 801-805. PMID: 23643302, DOI: 10.1053/j.ajkd.2013.02.376.Peer-Reviewed Case Reports and Technical NotesConceptsAcute kidney injuryAcute tubular injuryKidney injuryTubular injuryDialysis-requiring acute kidney injuryAcute interstitial nephritisMultiorgan system failureSubsequent kidney biopsySevere symptomatic diseaseUrinary macrophagesUrinary findingsInterstitial nephritisKidney biopsySymptomatic diseaseMassive hemolysisSevere babesiosisVolume depletionCommon causeProfound hemolysisErythrocyte fragmentsUrine sedimentInjuryLarge macrophagesPigment toxicityUnique finding
2011
Risk of Poor Outcomes with Novel and Traditional Biomarkers at Clinical AKI Diagnosis
Hall IE, Coca SG, Perazella MA, Eko UU, Luciano RL, Peter PR, Han WK, Parikh CR. Risk of Poor Outcomes with Novel and Traditional Biomarkers at Clinical AKI Diagnosis. Clinical Journal Of The American Society Of Nephrology 2011, 6: 2740-2749. PMID: 22034509, PMCID: PMC3255362, DOI: 10.2215/cjn.04960511.Peer-Reviewed Original ResearchConceptsKidney injury molecule-1Neutrophil gelatinase-associated lipocalinAcute kidney injuryAcute tubular necrosisMicroscopy scorePrimary outcomeIL-18Prognostic utilityClinical assessmentInjury molecule-1Peak serum creatinineProspective cohort studyGelatinase-associated lipocalinFirst dayUrine protein biomarkersProtein biomarker concentrationsAKI criteriaAKI diagnosisAKI stageBaseline GFRHospital deathKidney injuryCohort studySerum creatinineTubular necrosis