2023
Uncovering the role of Rad51 in homologous recombination-mediated antigenic diversification in the human malaria parasite Plasmodium falciparum
Vydyam P, Roy N, Bhattacharyya M. Uncovering the role of Rad51 in homologous recombination-mediated antigenic diversification in the human malaria parasite Plasmodium falciparum. Frontiers In Molecular Biosciences 2023, 10: 1223682. PMID: 37593128, PMCID: PMC10427863, DOI: 10.3389/fmolb.2023.1223682.Peer-Reviewed Original ResearchRecombination eventsHuman malaria parasite Plasmodium falciparumAntigenic variationMalaria parasite Plasmodium falciparumRole of RAD51Generation of diversityWhole genome sequencing approachParasite Plasmodium falciparumHuman malaria parasiteMultigene familyGene diversificationRecombinase functionGene repertoireHomologous recombinationGenomic rearrangementsSequencing approachSequence rearrangementsKey molecular factorsParasite linesMolecular determinantsAntigenic diversificationMalaria parasitesChronicity of infectionMolecular factorsImmune evasion mechanisms
2019
A small-molecule inhibitor of the DNA recombinase Rad51 from Plasmodium falciparum synergizes with the antimalarial drugs artemisinin and chloroquine
Vydyam P, Dutta D, Sutram N, Bhattacharyya S, Bhattacharyya M. A small-molecule inhibitor of the DNA recombinase Rad51 from Plasmodium falciparum synergizes with the antimalarial drugs artemisinin and chloroquine. Journal Of Biological Chemistry 2019, 294: 8171-8183. PMID: 30936202, PMCID: PMC6527153, DOI: 10.1074/jbc.ra118.005009.Peer-Reviewed Original ResearchConceptsMultidrug-resistant parasitesAnti-parasitic activitySmall molecule inhibitorsMalaria drugsAntimalarial drugsChloroquinePotential drug targetsAntigenic diversityAntimalarial activityCell linesParasitic DNADNA double-strand breaksSpecific inhibitorDrug targetsDrugsInhibitorsParasitesPfRad51DNA-damaging agentsHigh affinityScreening approachFindingsHomologous recombinationMammalian cell linesActivity