1992
Molecular regulation of tumor necrosis factor-alpha and lymphotoxin production in T cells. Inhibition by prostaglandin E2.
Ferreri NR, Sarr T, Askenase PW, Ruddle NH. Molecular regulation of tumor necrosis factor-alpha and lymphotoxin production in T cells. Inhibition by prostaglandin E2. Journal Of Biological Chemistry 1992, 267: 9443-9449. PMID: 1533632, DOI: 10.1016/s0021-9258(19)50443-4.Peer-Reviewed Original ResearchConceptsTNF-alphaProstaglandin E2T cell clonesT cellsTumor necrosisLymphotoxin productionLT productionMajor histocompatibility complex class IIHistocompatibility complex class IICell clonesPresence of PGE2M prostaglandin E2Dose-dependent mannerPGF2 alphaSoluble concanavalin ALeukotriene C4Murine Th1Inhibited productionClass IIFibrosarcoma cell lineInhibitory effectMurine fibrosarcoma cell lineBiological activityConcanavalin ACell lines
1977
Studies on the role of the thymus and T cells in the in vivo suppression of delayed hypersensitivity (desensitization): radiosensitivity of the mechanism inducing nonspecific anergy.
Thestrup-Pedersen K, Dwyer J, Askenase P. Studies on the role of the thymus and T cells in the in vivo suppression of delayed hypersensitivity (desensitization): radiosensitivity of the mechanism inducing nonspecific anergy. The Journal Of Immunology 1977, 118: 1665-71. PMID: 300755, DOI: 10.4049/jimmunol.118.5.1665.Peer-Reviewed Original ResearchConceptsT cellsDelayed hypersensitivitySuppression of delayed hypersensitivityDoses of whole-body irradiationNonspecific desensitizationMature T cellsWhole-body irradiationMono-nuclear cellsIn vivo suppressionThymic weightImmunoregulatory mechanismsPeripheral bloodRadiosensitive cellsAssociated with 1AnergySmall dosesDecreased responseGuinea pigsSkin sitesDesensitizationAntigenDesensitized stateConcanavalin AHypersensitivityCells